PUBLICATION
A quantitative approach to study the adaptation of rhythmic eye movements and the resulting tonic eye deviation in larval zebrafish
- Authors
- Lin, T.F., Huang, M.Y.
- ID
- ZDB-PUB-230614-39
- Date
- 2023
- Source
- Journal of neuroscience research 101(9): 1504-1518 (Journal)
- Registered Authors
- Huang, Melody Ying-Yu
- Keywords
- adaptation, larval zebrafish, optokinetic response, quick phase, spontaneous saccade
- MeSH Terms
-
- Adaptation, Physiological
- Animals
- Larva
- Nystagmus, Optokinetic*
- Reflex/physiology
- Zebrafish*/physiology
- PubMed
- 37313595 Full text @ J. Neurosci. Res.
Citation
Lin, T.F., Huang, M.Y. (2023) A quantitative approach to study the adaptation of rhythmic eye movements and the resulting tonic eye deviation in larval zebrafish. Journal of neuroscience research. 101(9):1504-1518.
Abstract
To optimize performance during vital tasks, animals are capable of tuning rhythmic neural signals that drive repetitive behaviors, such as motor reflexes under constant sensory stimuli. In the oculomotor system, animals track the moving image during slow phases while repetitively resetting the eye position from the eccentricity during quick phases. During optokinetic response (OKR), larval zebrafish occasionally show a delayed quick phase; thus, the eyes remain tonically deviated from the center. In this study, we scrutinized OKR in larval zebrafish under a broad range of stimulus velocities to determine the parametric property of the quick-phase delay. A prolonged stimulation revealed that the slow-phase (SP) duration-the interval between two quick phases-was tuned increasingly over time toward a homeostatic range, regardless of stimulus velocity. Attributed to this rhythm control, larval zebrafish exhibited a tonic eye deviation following slow phases, which was especially pronounced when tracking a fast stimulus over an extended time period. In addition to the SP duration, the fixation duration between spontaneous saccades in darkness also revealed a similar adaptive property after the prolonged optokinetic stimulation. Our results provide a quantitative description of the adaptation of rhythmic eye movements in developing animals and pave the way for potential animal models for eye movement disorders.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping