PUBLICATION
Roles of the 5-HT2C receptor on zebrafish sociality
- Authors
- de Moura, L.A., Pyterson, M.P., Pimentel, A.F.N., Araújo, F., de Souza, L.V.X.B., Mendes, C.H.M., Costa, B.P.D., de Siqueira-Silva, D.H., Lima-Maximino, M., Maximino, C.
- ID
- ZDB-PUB-230418-59
- Date
- 2023
- Source
- Progress in neuro-psychopharmacology & biological psychiatry 125: 110769 (Journal)
- Registered Authors
- Maximino, Caio
- Keywords
- 5-HT2C receptors, Aggression, Cooperation, Social investigation, Social novelty, Social plasticity
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology
- Receptor, Serotonin, 5-HT2C*
- Serotonin
- Social Behavior
- Zebrafish*/physiology
- PubMed
- 37068544 Full text @ Prog. Neuropsychopharmacol. Biol. Psychiatry
Citation
de Moura, L.A., Pyterson, M.P., Pimentel, A.F.N., Araújo, F., de Souza, L.V.X.B., Mendes, C.H.M., Costa, B.P.D., de Siqueira-Silva, D.H., Lima-Maximino, M., Maximino, C. (2023) Roles of the 5-HT2C receptor on zebrafish sociality. Progress in neuro-psychopharmacology & biological psychiatry. 125:110769.
Abstract
Serotonin (5-HT) receptors have been implicated in social behavior in vertebrates. Zebrafish (Danio rerio) have been increasingly being used behavioral neuroscience to study the neurobiological correlates of behavior, including sociality. Nonetheless, the role of 5-HT2C receptors in different social functions were not yet studied in this species. Zebrafish were treated with the agonist MK-212 (2 mg/kg) or the antagonist RS-102221 (2 mg/kg) and tested in the social interaction and social novelty tests, conditional approach test, or mirror-induced aggressive displays. MK-212 increased preference for an unknown conspecific in the social investigation test, but also increased preference for the known conspecific in the social novelty test; RS-102221, on the other hand, decreased preference in the social investigation test but increased preference for the novel conspecific in the social novelty test. MK-212 also decreased predator inspection in the conditional approach test. While RS-102221 decreased time in the display zone in the mirror-induced aggressive display test, it increased display duration. Overall, these results demonstrate the complex role of 5-HT2C receptors in different social contexts in zebrafish, revealing a participation in social plasticity in vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping