PUBLICATION
Toxicity and ecological risk assessment for two AhR agonistic pesticides mepanipyrim and cyprodinil and their metabolites
- Authors
- Shen, C., Tang, C., Zhu, K., He, C., Yang, C., Zuo, Z.
- ID
- ZDB-PUB-230402-49
- Date
- 2023
- Source
- Environmental science and pollution research international 30(20): 58944-58955 (Journal)
- Registered Authors
- He, Chengyong
- Keywords
- AhR agonists, Danio rerio, Ecological risk assessment, Metabolites, Pesticides
- MeSH Terms
-
- Animals
- Cytochrome P-450 CYP1A1/metabolism
- Embryo, Nonmammalian/metabolism
- Pesticides*/metabolism
- Pesticides*/toxicity
- Receptors, Aryl Hydrocarbon/metabolism
- Zebrafish*
- PubMed
- 37002518 Full text @ Environ. Sci. Pollut. Res. Int.
Citation
Shen, C., Tang, C., Zhu, K., He, C., Yang, C., Zuo, Z. (2023) Toxicity and ecological risk assessment for two AhR agonistic pesticides mepanipyrim and cyprodinil and their metabolites. Environmental science and pollution research international. 30(20):58944-58955.
Abstract
Mepanipyrim and cyprodinil are widely used to control and/or prevent fungal diseases in fruit culture. They are frequently detected in the aquatic environment and some food commodities. Different from TCDD, mepanipyrim and cyprodinil are more easily metabolised in the environments. However, the risk of their metabolites to the ecological environment is unclear and needs to be further confirmed. In this study, we investigated the temporal pattern of mepanipyrim- and cyprodinil-induced CYP1A and AhR2 expression and EROD enzyme activity at different time frames during zebrafish embryonic and larval development. Then, we assessed the ecological risk of mepanipyrim, cyprodinil, and their metabolites to aquatic organisms. Our results showed that mepanipyrim and cyprodinil exposure could increase the expression level of cyp1a and ahr2 genes and EROD activity by a dynamic pattern in different developmental stages of zebrafish. Besides, their several metabolites showed strong AhR agonistic activity. Importantly, these metabolites could cause potential ecological risks to aquatic organisms and should be paid more attention to. Our results would provide an important reference value for environmental pollution control and the use management of mepanipyrim and cyprodinil.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping