PUBLICATION
The multifaceted nature of endogenous cardiac regeneration
- Authors
- Rolland, L., Jopling, C.
- ID
- ZDB-PUB-230401-43
- Date
- 2023
- Source
- Frontiers in cardiovascular medicine 10: 11384851138485 (Review)
- Registered Authors
- Jopling, Chris
- Keywords
- cardiomyocyte, heart, hypoxia, inflammation, neonatal mouse, regeneration, zebrafish
- MeSH Terms
- none
- PubMed
- 36998973 Full text @ Front Cardiovasc Med
Citation
Rolland, L., Jopling, C. (2023) The multifaceted nature of endogenous cardiac regeneration. Frontiers in cardiovascular medicine. 10:11384851138485.
Abstract
Since the first evidence of cardiac regeneration was observed, almost 50 years ago, more studies have highlighted the endogenous regenerative abilities of several models following cardiac injury. In particular, analysis of cardiac regeneration in zebrafish and neonatal mice has uncovered numerous mechanisms involved in the regenerative process. It is now apparent that cardiac regeneration is not simply achieved by inducing cardiomyocytes to proliferate but requires a multifaceted response involving numerous different cell types, signaling pathways and mechanisms which must all work in harmony in order for regeneration to occur. In this review we will endeavor to highlight a variety of processes that have been identifed as being essential for cardiac regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping