PUBLICATION
Thalamic regulation of a visual critical period and motor behavior
- Authors
- Hageter, J., Starkey, J., Horstick, E.J.
- ID
- ZDB-PUB-230324-45
- Date
- 2023
- Source
- Cell Reports 42: 112287112287 (Journal)
- Registered Authors
- Horstick, Eric
- Keywords
- CP: Developmental biology, CP: Neuroscience, critical period, functional asymmetry, inhibitory signaling, motor regulation, ocular dominance, optogenetics, plasticity, thalamus, visual plasticity, zebrafish
- MeSH Terms
-
- Animals
- Critical Period, Psychological
- Neuronal Plasticity/physiology
- Neurons
- Thalamus/physiology
- Visual Cortex*/physiology
- Zebrafish*
- PubMed
- 36952349 Full text @ Cell Rep.
Citation
Hageter, J., Starkey, J., Horstick, E.J. (2023) Thalamic regulation of a visual critical period and motor behavior. Cell Reports. 42:112287112287.
Abstract
During the visual critical period (CP), sensory experience refines the structure and function of visual circuits. The basis of this plasticity was long thought to be limited to cortical circuits, but recently described thalamic plasticity challenges this dogma and demonstrates greater complexity underlying visual plasticity. Yet how visual experience modulates thalamic neurons or how the thalamus modulates CP timing is incompletely understood. Using a larval zebrafish, thalamus-centric ocular dominance model, we show functional changes in the thalamus and a role of inhibitory signaling to establish CP timing using a combination of functional imaging, optogenetics, and pharmacology. Hemisphere-specific changes in genetically defined thalamic neurons correlate with changes in visuomotor behavior, establishing a role of thalamic plasticity in modulating motor performance. Our work demonstrates that visual plasticity is broadly conserved and that visual experience leads to neuron-level functional changes in the thalamus that require inhibitory signaling to establish critical period timing.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping