PUBLICATION

bdnf loss affects activity, sociability, and anxiety-like behaviour in zebrafish

Authors
Lucon-Xiccato, T., Tomain, M., D'Aniello, S., Bertolucci, C.
ID
ZDB-PUB-220920-29
Date
2022
Source
Behavioural brain research   436: 114115 (Journal)
Registered Authors
Bertolucci, Cristiano, D'Aniello, Salvatore, Lucon-Xiccato, Tyrone
Keywords
Danio rerio, anxiety, fish behaviour, neurotrophins, open-field test, social behaviour
MeSH Terms
  • Animals
  • Anxiety
  • Behavior, Animal
  • Brain-Derived Neurotrophic Factor*
  • Humans
  • Neuronal Plasticity
  • Swimming/physiology
  • Zebrafish*/physiology
PubMed
36113727 Full text @ Behav. Brain Res.
Citation
Lucon-Xiccato, T., Tomain, M., D'Aniello, S., Bertolucci, C. (2022) bdnf loss affects activity, sociability, and anxiety-like behaviour in zebrafish. Behavioural brain research. 436:114115.
Abstract
Brain-derived neurotropic factor (BDNF) has established roles in neuronal survival and differentiation, in synaptic plasticity, and in neurotransmitters release. Several lines of evidence suggest that variations in BDNF might alter behaviour and contribute to neurobehavioural disorders. We investigated the functional effects of BDNF loss on behaviour by phenotyping a recently-generated CRISPR/Cas9 bdnf-/- zebrafish line through a battery of behavioural assays. Results of two behavioural tests suggested higher levels of locomotor activity in bdnf-/- zebrafish compared to bdnf+/+ zebrafish, in spite of similar swimming capacities observed in the two lines in a swim tunnel. bdnf-/- zebrafish also displayed higher levels of attraction towards a social stimulus compared to wild-type zebrafish, suggesting an effect of BDNF in sociability. Last, in a scototaxis test, we found evidence of potential differences in anxiety-like behaviour between the two lines. Our study supports an effect of BDNF on several behavioural traits, in line with early studies in mutant rodent models and in humans, suggesting the possibility to use the zebrafish to investigate diseases that involve alteration in BDNF levels.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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