PUBLICATION
Comparative toxicity of [C8mim]Br and [C8py]Br in early developmental stages of zebrafish (Danio rerio) with focus on oxidative stress, apoptosis, and neurotoxicity
- Authors
- Wang, H., Wang, X., Jia, J., Qin, Y., Chen, S., Wang, S., Martyniuk, C.J., Bing, Y.
- ID
- ZDB-PUB-220419-18
- Date
- 2022
- Source
- Environmental Toxicology and Pharmacology 92: 103864 (Journal)
- Registered Authors
- Keywords
- apoptosis, ionic liquids, neurotoxicity, oxidative stress, zebrafish embryos
- MeSH Terms
-
- Animals
- Apoptosis
- Bromides/pharmacology
- Cations
- Ecosystem
- Ionic Liquids*
- Oxidative Stress
- Zebrafish*
- PubMed
- 35430362 Full text @ Environ. Toxicol. Pharmacol.
Citation
Wang, H., Wang, X., Jia, J., Qin, Y., Chen, S., Wang, S., Martyniuk, C.J., Bing, Y. (2022) Comparative toxicity of [C8mim]Br and [C8py]Br in early developmental stages of zebrafish (Danio rerio) with focus on oxidative stress, apoptosis, and neurotoxicity. Environmental Toxicology and Pharmacology. 92:103864.
Abstract
The increasing production and usage of ionic liquids (ILs) have raised global ecotoxicological concerns regarding their release into the environment. While the effects of side chains on the IL-induced toxicity in various aquatic organisms have been well-recognized, the role of cationic cores in determining their ecotoxicity remains to be elucidated. Herein, the comparative bioavailability and toxicity of two ILs with different cationic cores but the same anion and side chain in zebrafish embryos were determined. 1-octyl-3-methylimidazolium bromide ([C8mim]Br) has higher accumulation in zebrafish, and triggered developmental toxicity by inducing oxidative stress and apoptosis. Meanwhile, 1-octyl-1-methylpyridium bromide ([C8py]Br) enhanced SOD activity and upregulated anti-apoptotic bcl-2 gene expression, contributing to its much lower neurodevelopmental toxicity. Our study demonstrates the vital role of cationic core in determining the developmental toxicity of ILs and highlights the need for further investigations into the toxicity of imidazolium and pyridinium based ILs in aquatic ecosystems.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping