PUBLICATION
Developmental toxicity and neurotoxicity assessment of R-, S-, and RS-propylene glycol enantiomers in zebrafish (Danio rerio) larvae
- Authors
- Shen, C., Zhao, X., He, C., Zuo, Z.
- ID
- ZDB-PUB-220111-4
- Date
- 2022
- Source
- Environmental science and pollution research international 29(20): 30537-30547 (Journal)
- Registered Authors
- He, Chengyong
- Keywords
- Danio rerio, Developmental toxicity, Enantiomers, Neurotoxicity, Propylene glycol
- MeSH Terms
-
- Animals
- Embryo, Nonmammalian
- Humans
- Larva
- Neurotoxicity Syndromes*
- Propylene Glycol
- Water Pollutants, Chemical*/toxicity
- Zebrafish
- PubMed
- 35000155 Full text @ Environ. Sci. Pollut. Res. Int.
Citation
Shen, C., Zhao, X., He, C., Zuo, Z. (2022) Developmental toxicity and neurotoxicity assessment of R-, S-, and RS-propylene glycol enantiomers in zebrafish (Danio rerio) larvae. Environmental science and pollution research international. 29(20):30537-30547.
Abstract
Propylene glycol (PG) is widely used in the foods, pharmaceuticals, oil industry, animal feed, cosmetics and other industries. Because of the existence of a chiral carbon center, PG forms R (Rectus)- and S (Sinister)-enantiomers. Currently, the toxicity study of its R-, S-enantiomers is still very scarce. In this study, we have assessed the developmental toxicity and neurotoxicity of the R-, S-, and RS-PG enantiomers in zebrafish larvae. We found that exposure to R-, S-, and RS-PG enantiomers did not significantly affect the basic developmental endpoints of embryos or larvae (i.e., embryonic movement, hatching, mortality, malformation, heartbeat, body length), indicating that R-, S-, and RS-PG exposures did not exhibit the basic developmental toxicity in zebrafish larvae. The toxicity of three enantiomers was lower than that of ethanol, and there was no significant difference between them. However, R-, S-, and RS-PG exposures with high doses could significantly change the eye diameter and locomotor activity of larval zebrafish, indicating that R-, S-, and RS-PG enantiomers of high doses could potentially exhibit the neurotoxicity and ocular developmental toxicity in zebrafish larvae. Therefore, the potential neurotoxicity and ocular developmental toxicity of R-, S-, and RS-PG enantiomers for infants and toddlers should be considered.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping