The eye tugs and the nose follows: how inter-tissue adhesion directs olfactory development
- Smith, S.J., Holley, S.A.
- EMBO reports 23(2): e54396 (Journal)
- Registered Authors
- Holley, Scott
- MeSH Terms
- Tissue Adhesions
- Zebrafish Proteins*/metabolism
- 34910840 Full text @ EMBO Rep.
Smith, S.J., Holley, S.A. (2021) The eye tugs and the nose follows: how inter-tissue adhesion directs olfactory development. EMBO reports. 23(2):e54396.
Embryonic development is a complex process in which cells divide, migrate, and differentiate in a precise spatiotemporal pattern. Cell-cell communication among neighboring cells plays a central role in specifying cell fate and in coordinating development. Embryonic development also relies on physical interaction between cells and coordinated changes in cell shape. A more recently investigated phenomenon is the coupling of development of adjacent tissues via inter-tissue adhesion. In this issue of EMBO Reports, Monnot and colleagues identify a role for inter-tissue adhesion in the development of adjacent sensory organs in the zebrafish. Specifically, eye morphogenesis influences the organ shape and retrograde axon growth in the adjacent olfactory placode via a shared extracellular matrix.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes