PUBLICATION
Genetically altered animal models for ATP1A3-related disorders
- Authors
- Ng, H.W.Y., Ogbeta, J.A., Clapcote, S.J.
- ID
- ZDB-PUB-211007-3
- Date
- 2021
- Source
- Disease models & mechanisms 14(10): (Review)
- Registered Authors
- Keywords
- ATP1A3, Animal models, Na+,K+-ATPase α3, Neurological disorders
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Disease Models, Animal*
- Humans
- Mutation
- Nervous System Diseases/genetics*
- Sodium-Potassium-Exchanging ATPase/genetics*
- Sodium-Potassium-Exchanging ATPase/metabolism
- PubMed
- 34612482 Full text @ Dis. Model. Mech.
Citation
Ng, H.W.Y., Ogbeta, J.A., Clapcote, S.J. (2021) Genetically altered animal models for ATP1A3-related disorders. Disease models & mechanisms. 14(10).
Abstract
Within the past 20 years, particularly with the advent of exome sequencing technologies, autosomal dominant and de novo mutations in the gene encoding the neurone-specific α3 subunit of the Na+,K+-ATPase (NKA α3) pump, ATP1A3, have been identified as the cause of a phenotypic continuum of rare neurological disorders. These allelic disorders of ATP1A3 include (in approximate order of severity/disability and onset in childhood development): polymicrogyria; alternating hemiplegia of childhood; cerebellar ataxia, areflexia, pes cavus, optic atrophy and sensorineural hearing loss syndrome; relapsing encephalopathy with cerebellar ataxia; and rapid-onset dystonia-parkinsonism. Some patients present intermediate, atypical or combined phenotypes. As these disorders are currently difficult to treat, there is an unmet need for more effective therapies. The molecular mechanisms through which mutations in ATP1A3 result in a broad range of neurological symptoms are poorly understood. However, in vivo comparative studies using genetically altered model organisms can provide insight into the biological consequences of the disease-causing mutations in NKA α3. Herein, we review the existing mouse, zebrafish, Drosophila and Caenorhabditis elegans models used to study ATP1A3-related disorders, and discuss their potential contribution towards the understanding of disease mechanisms and development of novel therapeutics.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping