PUBLICATION
Valveless pumping behavior of the simulated embryonic heart tube as a function of contractile patterns and myocardial stiffness
- Authors
- Sharifi, A., Gendernalik, A., Garrity, D., Bark, D.
- ID
- ZDB-PUB-210729-8
- Date
- 2021
- Source
- Biomechanics and Modeling in Mechanobiology 20(5): 2001-2012 (Journal)
- Registered Authors
- Garrity, Deborah
- Keywords
- Embryonic zebrafish heart, Fluid–structure interaction, Heart tube, Pumping, Pumping mechanics, Stiffness, Valveless pumping at low Reynolds number
- MeSH Terms
-
- Animals
- Biomechanical Phenomena
- Cardiac Output
- Computer Simulation
- Electric Impedance
- Heart/embryology*
- Heart/physiology*
- Heart Rate
- Hemodynamics*
- Models, Cardiovascular
- Models, Theoretical
- Myocardial Contraction*
- Myocardium/pathology*
- Peristalsis
- Pressure
- Stress, Mechanical
- Zebrafish/embryology*
- PubMed
- 34297252 Full text @ Biomech. Model. Mechanobiol.
Citation
Sharifi, A., Gendernalik, A., Garrity, D., Bark, D. (2021) Valveless pumping behavior of the simulated embryonic heart tube as a function of contractile patterns and myocardial stiffness. Biomechanics and Modeling in Mechanobiology. 20(5):2001-2012.
Abstract
During development, the heart begins pumping as a valveless multilayered tube capable of driving blood flow throughout the embryonic vasculature. The mechanical properties and how they interface with pumping function are not well-defined at this stage. Here, we evaluate pumping patterns using a fluid-structure interaction computational model, combined with experimental data and an energetic analysis to investigate myocardial mechanical properties. Through this work, we propose that a myocardium modeled as a Neo-Hookean material with a material constant on the order of 10 kPa is necessary for the heart tube to function with an optimal pressure and cardiac output.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping