PUBLICATION
Interspecies Behavioral Variability of Medaka Fish Assessed by Comparative Phenomics
- Authors
- Audira, G., Siregar, P., Chen, K.H., Roldan, M.J.M., Huang, J.C., Lai, H.T., Hsiao, C.D.
- ID
- ZDB-PUB-210603-40
- Date
- 2021
- Source
- International Journal of Molecular Sciences 22(11): (Journal)
- Registered Authors
- Hsiao, Chung-Der
- Keywords
- behavior, interspecies, medaka, phenomics
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology*
- Brain/enzymology*
- Fish Proteins*/biosynthesis
- Fish Proteins*/genetics
- Gene Expression Regulation, Enzymologic/physiology*
- NADH Dehydrogenase*/biosynthesis
- NADH Dehydrogenase*/genetics
- Oryzias*/genetics
- Oryzias*/metabolism
- Species Specificity
- PubMed
- 34073632 Full text @ Int. J. Mol. Sci.
Citation
Audira, G., Siregar, P., Chen, K.H., Roldan, M.J.M., Huang, J.C., Lai, H.T., Hsiao, C.D. (2021) Interspecies Behavioral Variability of Medaka Fish Assessed by Comparative Phenomics. International Journal of Molecular Sciences. 22(11):.
Abstract
Recently, medaka has been used as a model organism in various research fields. However, even though it possesses several advantages over zebrafish, fewer studies were done in medaka compared to zebrafish, especially with regard to its behavior. Thus, to provide more information regarding its behavior and to demonstrate the behavioral differences between several species of medaka, we compared the behavioral performance and biomarker expression in the brain between four medaka fishes, Oryzias latipes, Oryzias dancena, Oryzias woworae, and Oryzias sinensis. We found that each medaka species explicitly exhibited different behaviors to each other, which might be related to the different basal levels of several biomarkers. Furthermore, by phenomics and genomic-based clustering, the differences between these medaka fishes were further investigated. Here, the phenomic-based clustering was based on the behavior results, while the genomic-based clustering was based on the sequence of the nd2 gene. As we expected, both clusterings showed some resemblances to each other in terms of the interspecies relationship between medaka and zebrafish. However, this similarity was not displayed by both clusterings in the medaka interspecies comparisons. Therefore, these results suggest a re-interpretation of several prior studies in comparative biology. We hope that these results contribute to the growing database of medaka fish phenotypes and provide one of the foundations for future phenomics studies of medaka fish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping