PUBLICATION
Zebrafish and Flavonoids: Adjuvants against Obesity
- Authors
- Montalbano, G., Mhalhel, K., Briglia, M., Levanti, M., Abbate, F., Guerrera, M.C., D'Alessandro, E., Laurà, R., Germanà, A.
- ID
- ZDB-PUB-210603-20
- Date
- 2021
- Source
- Molecules 26(10): (Review)
- Registered Authors
- Briglia, Marilena, Germanà, Antonino, Guerrera, Maria Cristina, Mhalhel, Kamel
- Keywords
- flavonoids, inflammation, metabolic syndrome, natural compounds, obesity, obesity models, polyphenols, zebrafish
- MeSH Terms
-
- Animals
- Diet
- Disease Models, Animal
- Flavonoids/pharmacology*
- Obesity/etiology
- Obesity/prevention & control*
- Zebrafish
- PubMed
- 34069388 Full text @ Molecules
Citation
Montalbano, G., Mhalhel, K., Briglia, M., Levanti, M., Abbate, F., Guerrera, M.C., D'Alessandro, E., Laurà, R., Germanà, A. (2021) Zebrafish and Flavonoids: Adjuvants against Obesity. Molecules. 26(10):.
Abstract
Obesity is a pathological condition, defined as an excessive accumulation of fat, primarily caused by an energy imbalance. The storage of excess energy in the form of triglycerides within the adipocyte leads to lipotoxicity and promotes the phenotypic switch in the M1/M2 macrophage. These changes induce the development of a chronic state of low-grade inflammation, subsequently generating obesity-related complications, commonly known as metabolic syndromes. Over the past decade, obesity has been studied in many animal models. However, due to its competitive aspects and unique characteristics, the use of zebrafish has begun to gain traction in experimental obesity research. To counteract obesity and its related comorbidities, several natural substances have been studied. One of those natural substances reported to have substantial biological effects on obesity are flavonoids. This review summarizes the results of studies that examined the effects of flavonoids on obesity and related diseases and the emergence of zebrafish as a model of diet-induced obesity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping