PUBLICATION
Penipyrols C-G and methyl-penipyrol A, α-pyrone polyketides from the mangrove derived fungus Penicillium sp. HDN-11-131
- Authors
- Wang, L., Shi, Y., Che, Q., Zhu, T., Zhang, G., Zhang, X., Li, M., Li, D.
- ID
- ZDB-PUB-210522-7
- Date
- 2021
- Source
- Bioorganic chemistry 113: 104975 (Journal)
- Registered Authors
- Keywords
- Diabetes, Polyketides, Zebrafish, α-Pyrone, β-cell regeneration, γ-Butyrolactone
- MeSH Terms
-
- Animals
- Dose-Response Relationship, Drug
- Hypoglycemic Agents/chemistry
- Hypoglycemic Agents/isolation & purification
- Hypoglycemic Agents/pharmacology*
- Insulin-Secreting Cells/drug effects*
- Molecular Structure
- Penicillium/chemistry*
- Polyketides/chemistry
- Polyketides/isolation & purification
- Polyketides/pharmacology*
- Pyrones/chemistry
- Pyrones/isolation & purification
- Pyrones/pharmacology*
- Regeneration/drug effects
- Structure-Activity Relationship
- Zebrafish
- PubMed
- 34020278 Full text @ Bioorg. Chem.
Citation
Wang, L., Shi, Y., Che, Q., Zhu, T., Zhang, G., Zhang, X., Li, M., Li, D. (2021) Penipyrols C-G and methyl-penipyrol A, α-pyrone polyketides from the mangrove derived fungus Penicillium sp. HDN-11-131. Bioorganic chemistry. 113:104975.
Abstract
Six new α-pyrone polyketides, penipyrols C-G (1-5) and methyl-penipyrol A (6), together with one biogenetically related known compound, penipyrol A (7), were isolated from the extract of fungus Penicillium sp. HDN-11-131. Their structures including the absolute configurations were established by extensive spectroscopic analysis, Mosher's method, and ECD calculations as well as biogenic considerations. Compounds 1-4 possess a rare skeleton featuring γ-butyrolactone linked to α-pyrone ring through double bond. Compound 1 can induce pancreatic β-cell regeneration in zebrafish at 10 μM, which demonstrated promising anti-diabetes potential.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping