PUBLICATION
On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis
- Authors
- Baeken, M.W., Behl, C.
- ID
- ZDB-PUB-210505-3
- Date
- 2021
- Source
- Journal of cellular biochemistry 123(1): 102-114 (Journal)
- Registered Authors
- Keywords
- BAG3, LIR domain, WW domain, autophagy, proteostasis
- MeSH Terms
-
- Adaptor Proteins, Signal Transducing/chemistry
- Adaptor Proteins, Signal Transducing/genetics
- Adaptor Proteins, Signal Transducing/metabolism*
- Animals
- Apoptosis Regulatory Proteins/chemistry
- Apoptosis Regulatory Proteins/genetics
- Apoptosis Regulatory Proteins/metabolism*
- Autophagy/physiology
- Cellular Senescence/physiology
- Evolution, Molecular
- Fungi/metabolism*
- Humans
- Phylogeny
- Plants/metabolism*
- Proteasome Endopeptidase Complex/metabolism
- Protein Domains
- Proteolysis
- Proteostasis/physiology*
- Signal Transduction/physiology*
- PubMed
- 33942360 Full text @ J. Cell. Biochem.
Citation
Baeken, M.W., Behl, C. (2021) On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis. Journal of cellular biochemistry. 123(1):102-114.
Abstract
The B-cell CLL 2-associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence and degeneration, BAG3 has exhibited an essential role often related to its capabilities to organize and remove aggregated proteins. Exciting studies in different species ranging from human, murine, zebrafish, and plant samples have delivered vital insights into BAG3s' (and other BAG proteins') functions and their regulations. However, so far no studies have addressed neither BAG3's evolution nor its phylogenetic position in the BAG family.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping