ZFIN ID: ZDB-PUB-210407-74
Molecular regulation of myocardial proliferation and regeneration
Zheng, L., Du, J., Wang, Z., Zhou, Q., Zhu, X., Xiong, J.W.
Date: 2021
Source: Cell regeneration (London, England)   10: 13 (Review)
Registered Authors: Xiong, Jing-Wei
Keywords: Cardiac regeneration, Cardiomyocyte proliferation, Mouse, Signaling pathways, Zebrafish
MeSH Terms: none
PubMed: 33821373 Full text @ Cell Regen (Lond)
Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed a sophisticated molecular network regulating cardiac regeneration in the zebrafish and neonatal mouse heart. Here, we review both the classical and recent literature on the molecular and cellular mechanisms underlying heart regeneration, with a particular focus on how injury triggers the cell-cycle re-entry of quiescent cardiomyocytes to replenish their massive loss after myocardial infarction or ventricular resection. We highlight several important signaling pathways for cardiomyocyte proliferation and propose a working model of how these injury-induced signals promote cardiomyocyte proliferation. Thus, this concise review provides up-to-date research progresses on heart regeneration for investigators in the field of regeneration biology.