PUBLICATION
A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals
- Authors
- Brezitski, K.D., Goff, A.W., DeBenedittis, P., Karra, R.
- ID
- ZDB-PUB-210304-10
- Date
- 2021
- Source
- Current cardiology reports 23: 29 (Review)
- Registered Authors
- Karra, Ravi
- Keywords
- Cardiomyocyte proliferation, Heart failure, Regeneration
- MeSH Terms
-
- Adult
- Animals
- Cell Proliferation
- Heart
- Humans
- Mammals
- Mice
- Myocytes, Cardiac
- Regeneration*
- Zebrafish*
- PubMed
- 33655359 Full text @ Curr Cardiol Rep
Citation
Brezitski, K.D., Goff, A.W., DeBenedittis, P., Karra, R. (2021) A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals. Current cardiology reports. 23:29.
Abstract
Purpose of review The replenishment of lost or damaged myocardium has the potential to reverse heart failure, making heart regeneration a goal for cardiovascular medicine. Unlike adult mammals, injury to the zebrafish or neonatal mouse heart induces a robust regenerative program with minimal scarring. Recent insights into the cellular and molecular mechanisms of heart regeneration suggest that the machinery for regeneration is conserved from zebrafish to mammals. Here, we will review conserved mechanisms of heart regeneration and their translational implications.
Recent findings Based on studies in zebrafish and neonatal mice, cardiomyocyte proliferation has emerged as a primary strategy for effecting regeneration in the adult mammalian heart. Recent work has revealed pathways for stimulating cardiomyocyte cell cycle reentry; potential developmental barriers for cardiomyocyte proliferation; and the critical role of additional cell types to support heart regeneration. Studies in zebrafish and neonatal mice have established a template for heart regeneration. Continued comparative work has the potential to inform the translation of regenerative biology into therapeutics.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping