PUBLICATION
New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Aspergillus austroafricanus Y32-2
- Authors
- Li, P., Zhang, M., Li, H., Wang, R., Hou, H., Li, X., Liu, K., Chen, H.
- ID
- ZDB-PUB-210213-5
- Date
- 2021
- Source
- Marine drugs 19(2): (Journal)
- Registered Authors
- Keywords
- Aspergillus austroafricanus, anti-inflammatory effects, marine-derived fungus, novel bioactive metabolites, pro-angiogenesis
- MeSH Terms
-
- Angiogenesis Inducing Agents/pharmacology
- Animals
- Anti-Inflammatory Agents/pharmacology
- Aspergillus/metabolism*
- Hep G2 Cells
- Humans
- Indole Alkaloids/chemistry
- Indole Alkaloids/isolation & purification*
- Indole Alkaloids/pharmacology
- Magnetic Resonance Spectroscopy
- Pteridines/chemistry
- Pteridines/isolation & purification*
- Pteridines/pharmacology
- Water Microbiology*
- Zebrafish
- PubMed
- 33572212 Full text @ Mar. Drugs
Citation
Li, P., Zhang, M., Li, H., Wang, R., Hou, H., Li, X., Liu, K., Chen, H. (2021) New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Aspergillus austroafricanus Y32-2. Marine drugs. 19(2):.
Abstract
Chemical investigation of secondary metabolites from the marine-derived fungus Aspergillus austroafricanus Y32-2 resulted in the isolation of two new prenylated indole alkaloid homodimers, di-6-hydroxydeoxybrevianamide E (1) and dinotoamide J (2), one new pteridine alkaloid asperpteridinate A (3), with eleven known compounds (4-14). Their structures were elucidated by various spectroscopic methods including HRESIMS and NMR, while their absolute configurations were determined by ECD calculations. Each compound was evaluated for pro-angiogenic, anti-inflammatory effects in zebrafish models and cytotoxicity for HepG2 human liver carcinoma cells. As a result, compounds 2, 4, 5, 7, 10 exhibited pro-angiogenic activity in a PTK787-induced vascular injury zebrafish model in a dose-dependent manner, compounds 7, 8, 10, 11 displayed anti-inflammatory activity in a CuSO4-induced zebrafish inflammation model, and compound 6 showed significant cytotoxicity against HepG2 cells with an IC50 value of 30 µg/mL.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping