PUBLICATION
Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos
- Authors
- Huang, Y., Xia, Y., Tao, Y., Jin, H., Ji, C., Aniagu, S., Chen, T., Jiang, Y.
- ID
- ZDB-PUB-210202-23
- Date
- 2021
- Source
- Toxicology 452: 152697 (Journal)
- Registered Authors
- Keywords
- AHR, Heart development, Oxidative stress, Resveratrol, Trichloroethylene, Zebrafish
- MeSH Terms
-
- Animals
- Cardiotonic Agents/pharmacology*
- Embryonic Development/drug effects*
- Embryonic Development/physiology
- Heart/drug effects*
- Heart/embryology*
- Resveratrol/pharmacology*
- Solvents/toxicity
- Trichloroethylene/toxicity*
- Zebrafish
- PubMed
- 33524428 Full text @ Toxicology
- CTD
- 33524428
Citation
Huang, Y., Xia, Y., Tao, Y., Jin, H., Ji, C., Aniagu, S., Chen, T., Jiang, Y. (2021) Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. Toxicology. 452:152697.
Abstract
Trichloroethylene (TCE), a prevalent environmental contaminant, has been shown to induce cardiac malformations. Resveratrol (RSV) is a natural polyphenolic compound exhibiting protective effects on heart development. To investigate if RSV could protect against TCE-induced heart defects, we exposed zebrafish embryos to TCE (10 ppb) in the presence or absence of RSV (1 μg/mL). Our results showed that RSV significantly attenuated TCE-induced heart defects in zebrafish embryos. The TCE-induced ROS (reactive oxygen species) generation, 8-OHdG (8-hydroxy-2`-deoxyguanosine) formation and cell proliferation were significantly counteracted by RSV. Moreover, RSV attenuated the TCE-induced changes in mRNA expression or activity of genes involved in AHR and Nrf2 signal pathways. We further showed that RSV might inhibit TCE-enhanced cell proliferation by rescuing the downregulation of the p53/p21 axis. In conclusion, our data demonstrates that RSV protects against the cardiac developmental toxicity of TCE by inhibiting AHR activity, oxidative stress and cell proliferation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping