PUBLICATION
Behaviorally consequential astrocytic regulation of neural circuits
- Authors
- Nagai, J., Yu, X., Papouin, T., Cheong, E., Freeman, M.R., Monk, K.R., Hastings, M.H., Haydon, P.G., Rowitch, D., Shaham, S., Khakh, B.S.
- ID
- ZDB-PUB-210103-2
- Date
- 2020
- Source
- Neuron 109(4): 576-596 (Review)
- Registered Authors
- Monk, Kelly
- Keywords
- Caenorhabditis elegans, Danio rerio, Drosophila melanogaster, Mus musculus, astrocyte, behavior, genetic disorders, glia, microcircuit, neuronal circuit
- MeSH Terms
-
- Animals
- Astrocytes/metabolism*
- Astrocytes/pathology
- Caenorhabditis elegans
- Drosophila
- Humans
- Mental Disorders/genetics
- Mental Disorders/metabolism*
- Mental Disorders/pathology
- Mice
- Nerve Net/metabolism*
- Nerve Net/pathology
- Neurons/metabolism*
- Neurons/pathology
- Species Specificity
- Zebrafish
- PubMed
- 33385325 Full text @ Neuron
Citation
Nagai, J., Yu, X., Papouin, T., Cheong, E., Freeman, M.R., Monk, K.R., Hastings, M.H., Haydon, P.G., Rowitch, D., Shaham, S., Khakh, B.S. (2020) Behaviorally consequential astrocytic regulation of neural circuits. Neuron. 109(4):576-596.
Abstract
Astrocytes are a large and diverse population of morphologically complex cells that exist throughout nervous systems of multiple species. Progress over the last two decades has shown that astrocytes mediate developmental, physiological, and pathological processes. However, a long-standing open question is how astrocytes regulate neural circuits in ways that are behaviorally consequential. In this regard, we summarize recent studies using Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, and Mus musculus. The data reveal diverse astrocyte mechanisms operating in seconds or much longer timescales within neural circuits and shaping multiple behavioral outputs. We also refer to human diseases that have a known primary astrocytic basis. We suggest that including astrocytes in mechanistic, theoretical, and computational studies of neural circuits provides new perspectives to understand behavior, its regulation, and its disease-related manifestations.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping