PUBLICATION
Mechanisms mediating suppression of globin gene transcription in Danio rerio nonerythroid cells
- Authors
- Petrova, N.V., Klimenko, N.S., Kovina, A.P., Ioudinkova, E.S., Gavrilov, A.A., Iarovaia, O.V., Razin, S.V.
- ID
- ZDB-PUB-201216-14
- Date
- 2020
- Source
- Biochimie 181: 96-99 (Journal)
- Registered Authors
- Keywords
- Gene repression, HDAC, Polycomb, α- and β-globin genes
- MeSH Terms
-
- Animals
- Transcription, Genetic*
- Zebrafish/genetics
- Zebrafish/metabolism*
- Zebrafish Proteins/biosynthesis*
- Zebrafish Proteins/genetics
- alpha-Globins/biosynthesis*
- alpha-Globins/genetics
- beta-Globins/biosynthesis*
- beta-Globins/genetics
- PubMed
- 33321129 Full text @ Biochimie
Citation
Petrova, N.V., Klimenko, N.S., Kovina, A.P., Ioudinkova, E.S., Gavrilov, A.A., Iarovaia, O.V., Razin, S.V. (2020) Mechanisms mediating suppression of globin gene transcription in Danio rerio nonerythroid cells. Biochimie. 181:96-99.
Abstract
We studied the repression of adult and embryo-larval genes of the major globin gene locus in D. rerio fibroblasts. The results obtained suggest that at least some of the globin genes are repressed by Polycomb, similarly to human α-globin genes. Furthermore, within two α/β globin gene pairs, repression of α-type and β-type genes appears to be mediated by different mechanisms, as increasing the level of histone acetylation can activate transcription of only β-type genes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping