PUBLICATION
The optomotor response of aging zebrafish reveals a complex relationship between visual motion characteristics and cholinergic system
- Authors
- Karaduman, A., Karoglu-Eravsar, E.T., Kaya, U., Aydin, A., Adams, M.M., Kafaligonul, H.
- ID
- ZDB-PUB-201124-8
- Date
- 2020
- Source
- Neurobiology of aging 98: 21-32 (Journal)
- Registered Authors
- Keywords
- Acetylcholine, Aging, Direction, Motion detection, Zebrafish
- MeSH Terms
-
- Acetylcholine/physiology*
- Aging/physiology*
- Animals
- Behavior, Animal/physiology*
- Female
- Genotype*
- Male
- Motion Perception/physiology*
- Motor Activity/physiology*
- Photic Stimulation
- Receptors, Cholinergic/physiology
- Vision, Ocular/physiology*
- Visual Perception/physiology*
- Zebrafish/genetics*
- Zebrafish/physiology*
- PubMed
- 33227566 Full text @ Neurobiol. Aging
Citation
Karaduman, A., Karoglu-Eravsar, E.T., Kaya, U., Aydin, A., Adams, M.M., Kafaligonul, H. (2020) The optomotor response of aging zebrafish reveals a complex relationship between visual motion characteristics and cholinergic system. Neurobiology of aging. 98:21-32.
Abstract
Understanding the principles underlying age-related changes in motion perception is paramount for improving the quality of life and health of older adults. However, the mechanisms underlying age-related alterations in this aspect of vision, which is essential for survival in a dynamic world, still remain unclear. Using optomotor responses to drifting gratings, we investigated age-related changes in motion detection of adult zebrafish (wild-type/AB-strain and achesb55/+ mutants with decreased levels of acetylcholinesterase). Our results pointed out negative optomotor responses that significantly depend on the spatial frequency and contrast level of stimulation, providing supporting evidence for the visual motion-driven aspect of this behavior mainly exhibited by adult zebrafish. Although there were no significant main effects of age and genotype, we found a significant three-way interaction between contrast level, age, and genotype. In the contrast domain, the changes in optomotor responses and thus in the detection of motion direction were age- and genotype-specific. Accordingly, these behavioral findings suggest a strong but complicated relationship between visual motion characteristics and the cholinergic system during neural aging.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping