PUBLICATION
Red LED light treatment promotes cognitive learning through up-regulation of trpm4 in zebrafish
- Authors
- You, M.S., Yang, W.B., Cheng, C.H., Yu, S., Chang, H.C., Yu, H.S.
- ID
- ZDB-PUB-201120-120
- Date
- 2020
- Source
- Journal of photochemistry and photobiology. B, Biology 213: 112073 (Journal)
- Registered Authors
- Keywords
- LED lighting, cCognitive learning, mMemory, trpa1b, trpm4, zZebrafish
- MeSH Terms
-
- Animals
- Brain
- Cognition/radiation effects*
- Color
- Disks Large Homolog 4 Protein/radiation effects
- Light
- Lighting
- Receptors, N-Methyl-D-Aspartate/radiation effects
- Skin
- TRPA1 Cation Channel/radiation effects
- TRPM Cation Channels/genetics
- TRPM Cation Channels/radiation effects*
- Up-Regulation/radiation effects
- Zebrafish
- PubMed
- 33186875 Full text @ J. Photochem. Photobiol. B
Citation
You, M.S., Yang, W.B., Cheng, C.H., Yu, S., Chang, H.C., Yu, H.S. (2020) Red LED light treatment promotes cognitive learning through up-regulation of trpm4 in zebrafish. Journal of photochemistry and photobiology. B, Biology. 213:112073.
Abstract
Although light emitting diodes (LEDs) are widely used in our daily lives, there is little research regarding LED light''s po.ssible effects on biological functions. We used a zebrafish animal model to investigate the long-term effects of white, blue and red LED lights on cognitive learning and memory recall. Our data suggest that these treatments had not only an impact on learning but also surprisingly long-lasting effects, particularly with regard to individuals treated with red light. The qPCR results revealed that the expression levels of trpm4, trpa1b, grin2aa and dlg4 in the skin were increased after monochromatic light treatment. Furthermore, the up-regulation of trpm4 in the brain may correlate to enhanced learning and memory following red-light treatment. Our results identify a light-based stimulation system for enhancing zebrafish learning, which has the potential to provide important insights into the relationship between LED lighting and animal behaviour.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping