PUBLICATION
Sodium dehydroacetate exposure decreases locomotor persistence and hypoxia tolerance in zebrafish
- Authors
- Huang, X., Zhao, X., Zhu, K., Ding, S., Shao, B.
- ID
- ZDB-PUB-201103-2
- Date
- 2020
- Source
- Environmental research 195: 110276 (Journal)
- Registered Authors
- Keywords
- DHA-S, Energy deficiency, Locomotor, Oxygen, Zebrafish
- MeSH Terms
-
- Animals
- Hypoxia
- Larva
- Pyrones*
- Zebrafish*
- PubMed
- 33131684 Full text @ Environ. Res.
Citation
Huang, X., Zhao, X., Zhu, K., Ding, S., Shao, B. (2020) Sodium dehydroacetate exposure decreases locomotor persistence and hypoxia tolerance in zebrafish. Environmental research. 195:110276.
Abstract
Environmental exposure to sodium dehydroacetate (DHA-S) is inevitable as DHA-S is a high-volume preservative widely used in cosmetics, processed foods and personal care products. DHA-S is absorbed rapidly when administered orally or on the skin and generally considered to be safe and well tolerated. However, DHA-S has recently been reported to induce weight loss and allergic contact dermatitis, yet little is known about how DHA-S affect the related biological processes. Here, we characterize the biological effects of DHA-S on zebrafish model by directly waterborne exposure. Zebrafish is susceptible to DHA-S exposure at early developmental stage. DHA-S decreased the hatch rate and locomotor persistence of zebrafish, and eventually induced lethality during the continuous exposure at relatively low concentrations of commonly addition. Acute DHA-S exposure decreased respiration capacity in larval zebrafish, promoted the expression of HIF-1α (hypoxia-inducible factor-1α) and caused rapid adult zebrafish death in 30 h. We further demonstrated that DHA-S inhibited the activity of succinate dehydrogenase (SDH) inducing respiratory chain interruption, energy deficiency and organic acids accumulation. These results suggest that the approved DHA-S may pose serious environmental/ecological pressures on the aquatic animal's migration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping