PUBLICATION
Effects of the tributyltin on the blood parameters, immune responses and thyroid hormone system in zebrafish
- Authors
- Li, Z.H., Li, P.
- ID
- ZDB-PUB-201003-13
- Date
- 2020
- Source
- Environmental pollution (Barking, Essex : 1987) 268: 115707 (Journal)
- Registered Authors
- Keywords
- Blood parameter, Immune response, Thyroid hormone system, Tributyltin, Zebrafish
- MeSH Terms
-
- Animals
- Immunity
- Thyroid Hormones
- Trialkyltin Compounds*/toxicity
- Water Pollutants, Chemical*/toxicity
- Zebrafish
- PubMed
- 33007597 Full text @ Environ. Pollut.
Citation
Li, Z.H., Li, P. (2020) Effects of the tributyltin on the blood parameters, immune responses and thyroid hormone system in zebrafish. Environmental pollution (Barking, Essex : 1987). 268:115707.
Abstract
Tributyltin (TBT) is a widely used organotin compound around the world and was frequently detected in surface waters, which would pose risk to aquatic organisms. However, the mechanisms of TBT-induced toxicity is not full clear. The present study investigated the effects of the tributyltin (TBT) on the blood parameters, immune responses and thyroid hormone system in zebrafish. Fish were exposed to sublethal concentrations of TBT (10 ng/L, 100 ng/L and 300 ng/L) for 6 weeks. The effects of long-term exposure to TBT on blood parameters (NH3, ammonia; GLU, glucose; TP, total proteins; CK, creatine kinase; ALT, alanine aminotransferase; AST, aspartate aminotransferase), immune responses (Lys, lysozyme; IgM, immunoglobulin M) and some indexes related thyroid hormone system (T3, 3,5,3'-triiodothyronine; T4, thyroxine) were measured in zebrafish, as well as the expression of genes related to immune responses and thyroid hormone system. Based on the results, the physiological-biochemical responses was significantly enhanced with an increase in TBT concentration, reflected by the abnormal blood indices, dysregulation of endocrine system and immunotoxicity in zebrafish under TBT stress. The present study greatly extends our understanding of adverse effects of TBT on aquatic organisms.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping