PUBLICATION
Diphlorethohydroxycarmalol Attenuates Palmitate-Induced Hepatic Lipogenesis and Inflammation
- Authors
- Cha, S.H., Hwang, Y., Heo, S.J., Jun, H.S.
- ID
- ZDB-PUB-201002-129
- Date
- 2020
- Source
- Marine drugs 18(9): (Journal)
- Registered Authors
- Keywords
- hepatic steatosis, lipogenesis, polyphenol, seaweed
- MeSH Terms
-
- Hep G2 Cells
- Heterocyclic Compounds, 3-Ring/isolation & purification
- Heterocyclic Compounds, 3-Ring/pharmacology*
- Humans
- Inflammation/pathology
- Inflammation/prevention & control*
- Lipogenesis/drug effects
- Liver/drug effects
- Liver/physiopathology
- Non-alcoholic Fatty Liver Disease/prevention & control*
- Palmitates/toxicity
- Phaeophyceae/chemistry*
- PubMed
- 32962167 Full text @ Mar. Drugs
Citation
Cha, S.H., Hwang, Y., Heo, S.J., Jun, H.S. (2020) Diphlorethohydroxycarmalol Attenuates Palmitate-Induced Hepatic Lipogenesis and Inflammation. Marine drugs. 18(9):.
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease, encompassing a range of conditions caused by lipid deposition within liver cells, and is also associated with obesity and metabolic diseases. Here, we investigated the protective effects of diphlorethohydroxycarmalol (DPHC), which is a polyphenol isolated from an edible seaweed, Ishige okamurae, on palmitate-induced lipotoxicity in the liver. DPHC treatment repressed palmitate-induced cytotoxicity, triglyceride content, and lipid accumulation. DPHC prevented palmitate-induced mRNA and protein expression of SREBP (sterol regulatory element-binding protein) 1, C/EBP (CCAAT-enhancer-binding protein) α, ChREBP (carbohydrate-responsive element-binding protein), and FAS (fatty acid synthase). In addition, palmitate treatment reduced the expression levels of phosphorylated AMP-activated protein kinase (AMPK) and sirtuin (SIRT)1 proteins, and DPHC treatment rescued this reduction. Moreover, DPHC protected palmitate-induced liver toxicity and lipogenesis, as well as inflammation, and enhanced AMPK and SIRT1 signaling in zebrafish. These results suggest that DPHC possesses protective effects against palmitate-induced toxicity in the liver by preventing lipogenesis and inflammation. DPHC could be used as a potential therapeutic or preventive agent for fatty liver diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping