PUBLICATION
Chrysin, but not flavone backbone, decreases anxiety-like behavior in animal screens
- Authors
- German-Ponciano, L.J., Dutra Costa, B.P., Feitosa, L.M., Campos, K.D.S., Nayara da Silva Chaves, S., Cueto-Escobedo, J., Lima-Maximino, M., Rodríguez-Landa, J.F., Maximino, C.
- ID
- ZDB-PUB-201002-124
- Date
- 2020
- Source
- Neurochemistry international 140: 104850 (Journal)
- Registered Authors
- Maximino, Caio
- Keywords
- Anxiety, Chrysin, Flavone, Rat, Zebrafish
- MeSH Terms
-
- Animals
- Anxiety/drug therapy*
- Anxiety/psychology
- Drug Evaluation, Preclinical/methods
- Flavones/pharmacology
- Flavones/therapeutic use*
- Flavonoids/pharmacology
- Flavonoids/therapeutic use*
- Locomotion/drug effects*
- Locomotion/physiology
- Male
- Maze Learning/drug effects*
- Maze Learning/physiology
- Rats
- Rats, Wistar
- Zebrafish
- PubMed
- 32961254 Full text @ Neurochem. Int.
Citation
German-Ponciano, L.J., Dutra Costa, B.P., Feitosa, L.M., Campos, K.D.S., Nayara da Silva Chaves, S., Cueto-Escobedo, J., Lima-Maximino, M., Rodríguez-Landa, J.F., Maximino, C. (2020) Chrysin, but not flavone backbone, decreases anxiety-like behavior in animal screens. Neurochemistry international. 140:104850.
Abstract
Chrysin (5,7-dihydroxyflavone), a nutraceutical flavonoid present in diverse plants, has a backbone structure shared with the flavone backbone, with additional hydroxyl groups that confers its antioxidant properties and effects at the GABAA receptor complex. However, whether these effects are due to the hydroxyl groups is unknown. Here we report the effects of chrysin or the flavone backbone (1 mg/kg) in rats subjected to the elevated plus-maze and the locomotor activity test, as well as in the zebrafish evaluated in light/dark model. Chrysin, but not flavone, increased entries and time in the open arms of the elevated plus-maze, as well as time on white compartment of the light/dark model in zebrafish. These effects were comparable to diazepam, and were devoid of motor effects in both tests, as well as in the locomotor activity test. On the other hand, flavone decreased risk assessment in the light/dark test but increased rearing in the locomotor activity test in rats, suggesting effects threat information gathering; important species differences suggest new avenues of research. It is suggested that the specific effects of chrysin in relation to flavone include more of a mechanism of action in which in addition to its action at the GABAA/benzodiazepine receptor complex also could be involved its free radical scavenging abilities, which require specific research. Preprint:https://doi.org/10.1101/575514; Data and scripts:https://github.com/lanec-unifesspa/chrysin.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping