PUBLICATION
Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces
- Authors
- Afanasenkau, D., Kalinina, D., Lyakhovetskii, V., Tondera, C., Gorsky, O., Moosavi, S., Pavlova, N., Merkulyeva, N., Kalueff, A.V., Minev, I.R., Musienko, P.
- ID
- ZDB-PUB-201002-116
- Date
- 2020
- Source
- Nature biomedical engineering 4(10): 1010-1022 (Journal)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- none
- MeSH Terms
-
- Animals
- Biocompatible Materials*
- Cats
- Dielectric Spectroscopy
- Electric Stimulation
- Equipment Design
- Female
- Ink
- Male
- Neuromuscular Monitoring/instrumentation
- Neuromuscular Monitoring/methods*
- Printing, Three-Dimensional*
- Prostheses and Implants*
- Rats, Wistar
- Sciatic Nerve/physiology
- Spinal Cord/physiology
- Urinary Bladder/physiology
- Zebrafish
- PubMed
- 32958898 Full text @ Nat Biomed Eng
Citation
Afanasenkau, D., Kalinina, D., Lyakhovetskii, V., Tondera, C., Gorsky, O., Moosavi, S., Pavlova, N., Merkulyeva, N., Kalueff, A.V., Minev, I.R., Musienko, P. (2020) Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces. Nature biomedical engineering. 4(10):1010-1022.
Abstract
Neuromuscular interfaces are required to translate bioelectronic technologies for application in clinical medicine. Here, by leveraging the robotically controlled ink-jet deposition of low-viscosity conductive inks, extrusion of insulating silicone pastes and in situ activation of electrode surfaces via cold-air plasma, we show that soft biocompatible materials can be rapidly printed for the on-demand prototyping of customized electrode arrays well adjusted to specific anatomical environments, functions and experimental models. We also show, with the monitoring and activation of neuronal pathways in the brain, spinal cord and neuromuscular system of cats, rats and zebrafish, that the printed bioelectronic interfaces allow for long-term integration and functional stability. This technology might enable personalized bioelectronics for neuroprosthetic applications.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping