PUBLICATION
Sesamin attenuates histological alterations, oxidative stress and expressions of immune-related genes in liver of zebrafish (Danio rerio) exposed to fluoride
- Authors
- Cao, J., Feng, C., Xie, L., Li, L., Chen, J., Yun, S., Guo, W., Wang, T., Wu, Y., Meng, R., Wang, G., He, X., Luo, Y.
- ID
- ZDB-PUB-200830-13
- Date
- 2020
- Source
- Fish & shellfish immunology 106: 715-723 (Journal)
- Registered Authors
- Keywords
- Fluoride, Immune-related enzymes, Immune-related gene, Liver, Oxidative stress, Sesamin
- MeSH Terms
-
- Animals
- Chemical and Drug Induced Liver Injury/genetics*
- Chemical and Drug Induced Liver Injury/immunology*
- Chemical and Drug Induced Liver Injury/veterinary
- Cytokines/genetics
- Dioxoles/pharmacology*
- Fluorides/toxicity*
- Gene Expression Regulation/drug effects
- Lignans/pharmacology*
- Liver/drug effects
- Liver/immunology
- Liver/pathology
- Male
- Oxidative Stress/drug effects
- Protective Agents/pharmacology*
- Water Pollutants, Chemical/toxicity*
- Zebrafish
- PubMed
- 32860904 Full text @ Fish Shellfish Immunol.
Citation
Cao, J., Feng, C., Xie, L., Li, L., Chen, J., Yun, S., Guo, W., Wang, T., Wu, Y., Meng, R., Wang, G., He, X., Luo, Y. (2020) Sesamin attenuates histological alterations, oxidative stress and expressions of immune-related genes in liver of zebrafish (Danio rerio) exposed to fluoride. Fish & shellfish immunology. 106:715-723.
Abstract
Sesamin is the main lignan in sesame and is reported to have many benefits and medicinal properties. However, its protective effects against fluoride-induced damage in the liver of zebrafish have not been elucidated. Our previous studies found that fluoride exposure caused damage to the liver of zebrafish. In the study, the effects of sesamin on oxidative stress and immune damage in liver of zebrafish exposed to fluoride were measured. The results indicated that fluoride exposure damaged the microstructures of liver, increased significantly the oxidative stress, decreased remarkably the activities of ACP, AKP, and LZM, and affected obviously the expressions of immune-related genes. Treatment with sesamin remarkably attenuated fluoride-induced liver damage in a dose-dependent manner, indicated by the histopathological observation. Furthermore, sesamin treatment also significantly inhibited the production of ROS and oxidative stress, such as the decrease of lipid peroxidation level and the increase of CAT and SOD activities in liver. Sesamin treatment reversed the activities of immune-related enzymes and the expressions of immune-related genes in liver exposed to fluoride. These findings suggested that sesamin could protect the liver from fluoride-induced immune damage by oxidative stress downstream-mediated changes in reversing the activities of immune-related enzymes and the expressions of immune-related genes. Taken together, sesamin plays an important role in maintaining hepatic health and preventing liver from toxic damage caused by fluoride.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping