PUBLICATION
Light triggering goldsomes enable local NO-generation and alleviate pathological vasoconstriction
- Authors
- Lee, I.J., Kao, P.T., Hung, S.A., Wang, Z.W., Lin, H.J., Chang, W.T., Yeh, C.S., Liau, I.
- ID
- ZDB-PUB-200811-1
- Date
- 2020
- Source
- Nanomedicine : nanotechnology, biology, and medicine 30: 102282 (Journal)
- Registered Authors
- Keywords
- Hypoxia, Intravascular optical catheter, Nitric oxide, Vasoconstriction, Zebrafish
- MeSH Terms
-
- Animals
- Gold/chemistry*
- Hydrophobic and Hydrophilic Interactions
- Light*
- Metal Nanoparticles/chemistry*
- Metal Nanoparticles/toxicity
- Nitric Oxide/biosynthesis*
- Nitric Oxide Donors/chemistry
- Nitric Oxide Donors/pharmacology
- Polylactic Acid-Polyglycolic Acid Copolymer/chemistry
- S-Nitrosoglutathione/chemistry
- Vasoconstriction/drug effects*
- Zebrafish/embryology
- PubMed
- 32771420 Full text @ Nanomedicine
Citation
Lee, I.J., Kao, P.T., Hung, S.A., Wang, Z.W., Lin, H.J., Chang, W.T., Yeh, C.S., Liau, I. (2020) Light triggering goldsomes enable local NO-generation and alleviate pathological vasoconstriction. Nanomedicine : nanotechnology, biology, and medicine. 30:102282.
Abstract
While nitric oxide (NO) can remedy vasoconstriction, inhalation of NO may cause systematic toxicity. We report a goldsome, which comprises a hollowed poly(lactic-co-glycolic acid) (PLGA) polymersome with S-nitrosoglutathione (GSNO, a NO donor) molecules and gold nanoparticles (Au NPs) incorporated in its hydrophilic core and hydrophobic membrane, respectively. Photothermal heating caused breakdown of polymersomes and enabled NO generation through reaction between GSNO and Au NPs. Photo-illumination at the zebrafish head led to local NO generation and selective cerebral vasodilation while had little effects in regions away from the illumination site, and effectively mitigated hypoxia induced cerebral vasoconstriction. We demonstrate a translational potential by showing photo-stimulated NO generation with a clinical intravascular optical catheter. In conclusion, the goldsome, which enables light stimulated local NO generation and can be delivered with clinical intravascular optical catheters, should extend applications of NO therapies while surmount limitations associated with systemic administration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping