PUBLICATION
A quantitative modelling approach to zebrafish pigment pattern formation
- Authors
- Owen, J.P., Kelsh, R.N., Yates, C.A.
- ID
- ZDB-PUB-200728-34
- Date
- 2020
- Source
- eLIFE 9: (Journal)
- Registered Authors
- Kelsh, Robert
- Keywords
- Danio rerio, Zebrafish, computational biology, danio, developmental biology, systems biology, zebrafish
- MeSH Terms
-
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/physiology
- Body Patterning/physiology*
- Pigmentation*
- Animals
- Models, Genetic
- Chromatophores/physiology*
- PubMed
- 32716296 Full text @ Elife
Citation
Owen, J.P., Kelsh, R.N., Yates, C.A. (2020) A quantitative modelling approach to zebrafish pigment pattern formation. eLIFE. 9:.
Abstract
Pattern formation is a key aspect of development. Adult zebrafish exhibit a striking striped pattern generated through the self-organisation of three different chromatophores. Numerous investigations have revealed a multitude of individual cell-cell interactions important for this self-organisation, but it has remained unclear whether these known biological rules were sufficient to explain pattern formation. To test this, we present an individual-based mathematical model incorporating all the important cell-types and known interactions. The model qualitatively and quantitatively reproduces wild type and mutant pigment pattern development. We use it to resolve a number of outstanding biological uncertainties, including the roles of domain growth and the initial iridophore stripe, and to generate hypotheses about the functions of leopard. We conclude that our rule-set is sufficient to recapitulate wild-type and mutant patterns. Our work now leads the way for further in silico exploration of the developmental and evolutionary implications of this pigment patterning system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping