ZFIN ID: ZDB-PUB-200728-22
Behavioral Signatures of a Developing Neural Code
Avitan, L., Pujic, Z., Mölter, J., McCullough, M., Zhu, S., Sun, B., Myhre, A.E., Goodhill, G.J.
Date: 2020
Source: Current biology : CB   30(17): 3352-3363.e5 (Journal)
Registered Authors: Pujic, Zac
Keywords: behavioral development, calcium imaging, individual differences, mutual information, neural assemblies, neural decoding, neural development, optic tectum, prey capture, zebrafish
MeSH Terms:
  • Animals
  • Behavior, Animal*
  • Exploratory Behavior
  • Larva/growth & development
  • Larva/physiology*
  • Neurons/cytology
  • Neurons/physiology*
  • Predatory Behavior/physiology*
  • Superior Colliculi/growth & development
  • Superior Colliculi/physiology*
  • Visual Pathways/physiology*
  • Zebrafish/growth & development
  • Zebrafish/physiology*
PubMed: 32710821 Full text @ Curr. Biol.
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ABSTRACT
During early life, neural codes must develop to appropriately transform sensory inputs into behavioral outputs. Here, we demonstrate a link between the maturity of neural coding in the visual brain and developmental changes in visually guided behavior. In zebrafish larvae, we show that visually driven hunting behavior improves from 4 to 15 days post-fertilization, becoming faster and more accurate. During the same period, population activity in parts of the optic tectum refines, improving decoding and information transmission for particular spatial positions. Remarkably, individual differences in decoding can predict each fish's hunting success. Together, these results help reveal how the neural codes required for a natural behavior emerge during development.
ADDITIONAL INFORMATION