PUBLICATION
The pigmentation interference of bisphenol F and bisphenol A
- Authors
- Mu, X., Liu, J., Yuan, L., Huang, Y., Qian, L., Wang, C.
- ID
- ZDB-PUB-200715-26
- Date
- 2020
- Source
- Environmental pollution (Barking, Essex : 1987) 266: 115139 (Journal)
- Registered Authors
- Keywords
- Bisphenol analogs, Depigmentation, Ligand binding energetics, Tyrosinase family, Zebrafish
- MeSH Terms
-
- Animals
- Benzhydryl Compounds*
- Humans
- Phenols
- Pigmentation
- Sulfones*
- PubMed
- 32663677 Full text @ Environ. Pollut.
Citation
Mu, X., Liu, J., Yuan, L., Huang, Y., Qian, L., Wang, C. (2020) The pigmentation interference of bisphenol F and bisphenol A. Environmental pollution (Barking, Essex : 1987). 266:115139.
Abstract
Bisphenol A (BPA) and bisphenol F (BPF) are widely distributed in the environment and daily consumptions, leading to exposure toward human and environmental animals. The potential risk of bisphenol analogs on pigment and skin health is not well documented. In this study, we found that 0.05 mg/L BPF (tolerated daily intake (TDI) value of BPA) affected the particle size and color density of zebrafish melanin. While BPA caused less depigmentation effect toward zebrafish with effective concentration of 5.0 mg/L. The downregulation of melanin synthases induced by BPF is associated with the reduction in melanin. Molecular dynamics indicated that both BPF and BPA could act as ligands of zebrafish and human Tyr family proteins; however, these compounds have completely different energetics and spatial steric effects, potentially explaining their varying depigmentation effects. Additionally, an in vitro assay using A375 melanoma cells demonstrated that the inhibitory effect of BPF on human melanin production was primarily attributed to Tyr inhibition. These findings provide an important basis for understanding the molecular mechanisms of BPF and BPA in melanin inhibition, and the results reflect the skin pigmentation interference risk of these compounds, which are ubiquitous in everyday personal products.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping