| ZFIN ID: ZDB-PUB-200618-6 |
NeuroExaminer: an all-glass microfluidic device for whole-brain in vivo imaging in zebrafish
Mattern, K., Trotha, J.W.V., Erfle, P., Köster, R.W., Dietzel, A.
| Date: | 2020 |
|---|---|
| Source: | Communications biology 3: 311 (Journal) |
| Registered Authors: | Köster, Reinhard W., von Trotha, Jakob |
| Keywords: | none |
| MeSH Terms: |
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| PubMed: | 32546816 Full text @ Commun Biol |
Citation
Mattern, K., Trotha, J.W.V., Erfle, P., Köster, R.W., Dietzel, A. (2020) NeuroExaminer: an all-glass microfluidic device for whole-brain in vivo imaging in zebrafish. Communications biology. 3:311.
ABSTRACT
While microfluidics enables chemical stimuli application with high spatio-temporal precision, light-sheet microscopy allows rapid imaging of entire zebrafish brains with cellular resolution. Both techniques, however, have not been combined to monitor whole-brain neural activity yet. Unlike conventional microfluidics, we report here an all-glass device (NeuroExaminer) that is compatible with whole-brain in vivo imaging using light-sheet microscopy and can thus provide insights into brain function in health and disease.
ADDITIONAL INFORMATION