PUBLICATION
From Tank to Treatment: Modeling Melanoma in Zebrafish
- Authors
- Frantz, W.T., Ceol, C.J.
- ID
- ZDB-PUB-200528-4
- Date
- 2020
- Source
- Cells 9(5): (Review)
- Registered Authors
- Ceol, Craig
- Keywords
- Melanoma, genetics, melanocytes, microenvironment, modeling, xenografts, zebrafish
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Genetic Predisposition to Disease
- Melanocytes/pathology
- Melanoma/genetics
- Melanoma/pathology*
- Neural Crest/pathology
- Zebrafish/physiology*
- PubMed
- 32455885 Full text @ Cells
Citation
Frantz, W.T., Ceol, C.J. (2020) From Tank to Treatment: Modeling Melanoma in Zebrafish. Cells. 9(5):.
Abstract
Melanoma is the deadliest form of skin cancer and one of few cancers with a growing incidence. A thorough understanding of its pathogenesis is fundamental to developing new strategies to combat mortality and morbidity. Zebrafish-due in large part to their tractable genetics, conserved pathways, and optical properties-have emerged as an excellent system to model melanoma. Zebrafish have been used to study melanoma from a single tumor initiating cell, through metastasis, remission, and finally into relapse. In this review, we examine seminal zebrafish studies that have advanced our understanding of melanoma.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping