PUBLICATION
Selective Decoating-Induced Activation of Supramolecularly Coated Toxic Nanoparticles for Multiple Applications
- Authors
- Gao, C., Kwong, C.H.T., Sun, C., Li, Z., Lu, S., Yang, Y.W., Lee, S.M., Wang, R.
- ID
- ZDB-PUB-200515-5
- Date
- 2020
- Source
- ACS applied materials & interfaces 12(23): 25604-25615 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Anti-Bacterial Agents/chemistry
- Anti-Bacterial Agents/therapeutic use*
- Anti-Bacterial Agents/toxicity
- Antineoplastic Agents/chemistry
- Antineoplastic Agents/therapeutic use*
- Antineoplastic Agents/toxicity
- Bridged-Ring Compounds/chemistry
- Bridged-Ring Compounds/toxicity
- Cell Line, Tumor
- Escherichia coli/drug effects
- Female
- Fluorides/chemistry
- Fluorides/radiation effects
- Gadolinium/chemistry
- Gadolinium/radiation effects
- Hyaluronic Acid/chemistry
- Hyaluronic Acid/toxicity
- Imidazoles/chemistry
- Imidazoles/toxicity
- Infrared Rays
- Mice, Inbred C57BL
- Microbial Sensitivity Tests
- Nanoparticles/chemistry
- Nanoparticles/radiation effects
- Nanoparticles/therapeutic use*
- Nanoparticles/toxicity
- Neoplasms/drug therapy*
- Paraquat/chemistry
- Paraquat/therapeutic use*
- Paraquat/toxicity
- Polyesters/chemistry
- Polyesters/toxicity
- Staphylococcal Infections/drug therapy*
- Staphylococcus aureus/drug effects
- Thulium/chemistry
- Thulium/radiation effects
- Ytterbium/chemistry
- Ytterbium/radiation effects
- Zebrafish
- PubMed
- 32406668 Full text @ ACS Appl. Mater. Interfaces
Citation
Gao, C., Kwong, C.H.T., Sun, C., Li, Z., Lu, S., Yang, Y.W., Lee, S.M., Wang, R. (2020) Selective Decoating-Induced Activation of Supramolecularly Coated Toxic Nanoparticles for Multiple Applications. ACS applied materials & interfaces. 12(23):25604-25615.
Abstract
In spite of rapid emergence of numerous nanoparticles (NPs) for biomedical applications, it is often challenging to precisely control, or effectively tame, the bioactivity/toxicity of NPs, thereby exhibiting limited applications in areas. Herein, we report the construction of hyaluronic acid (HA) laminated, otherwise toxic methylviologen (MV) NPs, via ternary host-guest complexation between cucurbit[8]uril (CB[8]), trans-azobenzene conjugated HA, and MV-functionalized polylactic acid NPs (MV-NPs). The high, non-specific toxicity of MV-NPs was effectively shielded (turned-off) by HA lamination, as demonstrated in cells, zebrafish, and mouse models. The supramolecular host-guest interactions mediated HA coating offered HA-MV-NPs several modalities, including hyaluronidase locally and photo-irradiation remotely, to precisely remove HA lamination on demand, thereby endowing materials with the capability of selective decoating-induced activation (DIA) for applications as a user-friendly herbicide, a selective antibacterial agent or an anticancer nanomedicine. This work offers facile supramolecular coating and DIA strategies to effectively tame and precisely control the bioactivity and toxicity of functional nanomaterials for diverse applications.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping