PUBLICATION
2,3,5,4'-tetrahydroxystilbence-2-O-β-D-glucoside attenuates hepatic steatosis via IKKβ/NF-κB and Keap1-Nrf2 pathways in larval zebrafish
- Authors
- Wang, C., Hu, N.H., Yu, L.Y., Gong, L.H., Dai, X.Y., Peng, C., Li, Y.X.
- ID
- ZDB-PUB-200511-12
- Date
- 2020
- Source
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 127: 110138 (Journal)
- Registered Authors
- Keywords
- 2,3,5,4'-Tetrahydroxystilbence-2-O-β-D-glucoside, Hepatic steatosis, High cholesterol diet, IKKβ/NF-κB pathway, Keap1-Nrf2 pathway, Larval zebrafish, Non-alcoholic fatty liver disease
- MeSH Terms
-
- Animals
- Cholesterol, Dietary/administration & dosage
- Disease Models, Animal
- Glucosides/pharmacology*
- Glucosides/therapeutic use
- I-kappa B Kinase/physiology*
- Kelch-Like ECH-Associated Protein 1/physiology*
- Lipid Metabolism/drug effects
- NF-E2-Related Factor 2/physiology*
- NF-kappa B/physiology*
- Non-alcoholic Fatty Liver Disease/drug therapy*
- Non-alcoholic Fatty Liver Disease/metabolism
- Oxidative Stress/drug effects
- Signal Transduction/drug effects
- Stilbenes/pharmacology*
- Stilbenes/therapeutic use
- Zebrafish
- Zebrafish Proteins/physiology*
- PubMed
- 32387861 Full text @ Biomed. Pharmacother.
Citation
Wang, C., Hu, N.H., Yu, L.Y., Gong, L.H., Dai, X.Y., Peng, C., Li, Y.X. (2020) 2,3,5,4'-tetrahydroxystilbence-2-O-β-D-glucoside attenuates hepatic steatosis via IKKβ/NF-κB and Keap1-Nrf2 pathways in larval zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 127:110138.
Abstract
With the improvement of people's living standards and the change of dietary habits, Non-alcoholic fatty liver disease (NAFLD) has gradually become one of the liver diseases that endanger human health around the world. However, there are no particularly effective drugs for NAFLD in the current market. Therefore, new drug candidates which could provide high efficacy and low toxicity are needed valuable for the prevention and treatment of NAFLD. 2,3,5,4'-tetrahydroxystilbence-2-O-β-D-glucoside (TSG) is extracted from Polygonum multiflorum Thunb., and has been widely used to treat a variety of chronic diseases in China. Recently, TSG has been reported to exert various biological activities in many studies, such as lipid-lowering, anti-inflammatory and anti-oxidant activities, which indicate that TSG may have the effect of improving NAFLD. After feeding 5% high cholesterol diet to 5 days post fertilization larval zebrafish for 10 days, hepatic steatosis larval zebrafish model was established successfully. Then the effect of TSG on the improvement of hepatic steatosis larval zebrafish was studied. Moreover, the potential mechanism of TSG on anti-NAFLD effect were studied using RT-qPCR methods from multiple pathogenesis aspects of lipogenesis, lipid-lowering, inflammation, and oxidant stress. To conclude, TSG attenuates hepatic steatosis via regulating lipid metabolism related pathway, IKKβ/NF-κB anti-inflammatory pathway and Keap1-Nrf2 anti-oxidant pathway.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping