PUBLICATION
Anti-inflammatory effect of a flavonoid-rich extract of orange juice in adult zebrafish subjected to Vibrio anguillarum-induced enteritis
- Authors
- Cirmi, S., Randazzo, B., Russo, C., Musumeci, L., Maugeri, A., Montalbano, G., Guerrera, M.C., Lombardo, G.E., Levanti, M.
- ID
- ZDB-PUB-200428-1
- Date
- 2020
- Source
- Natural Product Research 35(23): 5350-5353 (Journal)
- Registered Authors
- Guerrera, Maria Cristina, Montalbano, Giuseppe
- Keywords
- Citrus sinensis, enteritis, enterocolitis, flavonoids, inflammation, orange juice, zebrafish
- MeSH Terms
-
- Animals
- Anti-Inflammatory Agents/pharmacology
- Citrus sinensis*
- Enteritis*/chemically induced
- Enteritis*/drug therapy
- Flavonoids/pharmacology
- Plant Extracts/pharmacology
- Vibrio
- Zebrafish
- PubMed
- 32338069 Full text @ Nat. Prod. Res.
Citation
Cirmi, S., Randazzo, B., Russo, C., Musumeci, L., Maugeri, A., Montalbano, G., Guerrera, M.C., Lombardo, G.E., Levanti, M. (2020) Anti-inflammatory effect of a flavonoid-rich extract of orange juice in adult zebrafish subjected to Vibrio anguillarum-induced enteritis. Natural Product Research. 35(23):5350-5353.
Abstract
Inflammation-related pathologies remain a serious health problem with high costs for the community. Citrus flavonoids are known to possess important pharmacological properties, including anti-inflammatory activity. In this study we evaluated the effects of a flavonoid-rich extract of orange juice (OJe) in an experimental model of enteritis induced by Vibrio anguillarum in adult zebrafish (Danio rerio). Administration of V. anguillarum through live feed (Artemia nauplii) for three consecutive days caused evident signs of enteritis in zebrafish. Three days of treatment with OJe before the pathogenic insult resulted in a remarkable reduction of tissue inflammatory events as well as a molecular down-regulation of the inflammatory genes such as IL-1β, IL-6 and TNFα. Our data suggest that OJe counteracts the inflammation of zebrafish intestinal mucosa, indicating that the pool of flavonoids present in orange juice could be useful for the prevention of enteritis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping