PUBLICATION
Neuroprotective role of taurine on MK-801-induced memory impairment and hyperlocomotion in zebrafish
- Authors
- Franscescon, F., Müller, T.E., Bertoncello, K.T., Rosemberg, D.B.
- ID
- ZDB-PUB-200229-9
- Date
- 2020
- Source
- Neurochemistry international 135: 104710 (Journal)
- Registered Authors
- Keywords
- glutamate excitotoxicity, inhibitory avoidance task, memory deficits, neuroprotection, schizophrenia, zebrafish.
- MeSH Terms
-
- Animals
- Dizocilpine Maleate/toxicity*
- Dose-Response Relationship, Drug
- Excitatory Amino Acid Antagonists/toxicity
- Female
- Gait Disorders, Neurologic/chemically induced
- Gait Disorders, Neurologic/physiopathology
- Gait Disorders, Neurologic/prevention & control*
- Male
- Memory Disorders/chemically induced
- Memory Disorders/physiopathology
- Memory Disorders/prevention & control*
- Neuroprotective Agents/pharmacology
- Neuroprotective Agents/therapeutic use*
- Taurine/pharmacology
- Taurine/therapeutic use*
- Zebrafish
- PubMed
- 32105720 Full text @ Neurochem. Int.
Citation
Franscescon, F., Müller, T.E., Bertoncello, K.T., Rosemberg, D.B. (2020) Neuroprotective role of taurine on MK-801-induced memory impairment and hyperlocomotion in zebrafish. Neurochemistry international. 135:104710.
Abstract
Schizophrenia is a neuropsychiatric condition that reaches around 1% of people worldwide. Because taurine exerts a neuroprotective role in the brain, this molecule is a promising candidate to reduce schizophrenia-like symptoms. Here, we investigated a possible neuroprotector role of taurine against MK-801-induced memory deficit and hyperlocomotion in zebrafish using the inhibitory avoidance task and the novel tank diving test, respectively. First, we assessed the influence of different MK-801 doses (0.1, 0.3, 0.5, 1 and 2 mg/kg, i.p.) on memory consolidation. Although all MK-801 doses tend to reduce the retention index, only 2 mg/kg MK-801 showed robust amnesic effects. Then, we evaluated whether taurine pretreatments (42, 150 and 400 mg/L for 60 min) prevent MK-801-induced cognitive impairment. Immediately after the training, animals were exposed to non-chlorinated water or taurine and subsequently challenged with 2 mg/kg MK-801, i.p. The test session was performed 24 hours after training. Although taurine alone did not change memory retention when compared with control, taurine pretreatments prevented MK-801-induced memory deficit. Importantly, no locomotor changes were observed 24 h after the training session. In the novel tank diving test, MK-801 induced hyperlocomotion and disrupted vertical activity, while 400 mg/L taurine pretreatment prevented these effects. Overall, our novel findings indicate a neuroprotective role of taurine against MK-801-induced memory deficit and hyperlocomotion, reinforcing the growing utility of zebrafish models to investigate the beneficial effects of different compounds against glutamate excitotoxicity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping