PUBLICATION
Exposure to Metalaxyl Disturbs the Skeletal Development of Zebrafish Embryos
- Authors
- Wu, Y., Xu, Z., Xu, X., Fan, L., Jiang, X.
- ID
- ZDB-PUB-200221-38
- Date
- 2020
- Source
- Bulletin of environmental contamination and toxicology 104(4): 432-437 (Journal)
- Registered Authors
- Keywords
- Embryonic development, Fish, Mechanism, Pesticide, Skeleton
- MeSH Terms
-
- Alanine/analogs & derivatives*
- Alanine/toxicity
- Animals
- Bone and Bones/drug effects*
- Bone and Bones/embryology
- Dose-Response Relationship, Drug
- Embryo, Nonmammalian/drug effects*
- Embryonic Development/drug effects*
- Larva/drug effects
- Larva/growth & development
- Water Pollutants, Chemical/toxicity*
- Zebrafish*
- PubMed
- 32072197 Full text @ Bull. Environ. Contam. Toxicol.
Citation
Wu, Y., Xu, Z., Xu, X., Fan, L., Jiang, X. (2020) Exposure to Metalaxyl Disturbs the Skeletal Development of Zebrafish Embryos. Bulletin of environmental contamination and toxicology. 104(4):432-437.
Abstract
Metalaxyl is broadly applied in agriculture to control peronosporales-caused diseases in plant. To investigate the toxic effects, zebrafish embryos were exposed to metalaxyl at 5, 50 and 500 ng/L for 72 h, the development of larvae were assessed. A significant decreased survival rate, body length, hatching rate (48 h post-fertilization), and a significant increased spinal curvature rate were observed in the 500 ng/L treatment. The lengths of lower jaw, upper jaw and hyomandibular were significantly decreased in the 5, 50 and 500 ng/L groups; while the lower jaw width was significantly increased in the 500 ng/L group. The lengths of palatoquadrate, ceratohyal and ethmoid plate were reduced. Though cyp26a1 mRNA levels showed no significant change, the transcription of bmp2b (in the 500 ng/L group), ihh (in the 50 and 500 ng/L groups), shh (in the 5, 50 and 500 ng/L groups) were significantly up-regulated, which may be related to the abnormal development of the skeleton.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping