PUBLICATION
Effects of chronic exposure to selenomethionine on social learning outcomes in zebrafish (Danio rerio): serotonergic dysregulation and oxidative stress in the brain
- Authors
- Attaran, A., Salahinejad, A., Naderi, M., Crane, A.L., Niyogi, S., Chivers, D.P.
- ID
- ZDB-PUB-200124-10
- Date
- 2020
- Source
- Chemosphere 247: 125898 (Journal)
- Registered Authors
- Keywords
- Escape latency, Lipid peroxidation, Selenium, Serotonin, Social learning
- MeSH Terms
-
- Animals
- Antioxidants/metabolism
- Brain/metabolism
- Diet
- Humans
- Learning
- Oxidative Stress/drug effects
- Oxidative Stress/physiology*
- Selenium/metabolism
- Selenomethionine/toxicity*
- Social Learning/drug effects
- Toxicity Tests, Chronic
- Water Pollutants, Chemical/toxicity*
- Zebrafish/metabolism
- Zebrafish/physiology*
- PubMed
- 31972490 Full text @ Chemosphere
Citation
Attaran, A., Salahinejad, A., Naderi, M., Crane, A.L., Niyogi, S., Chivers, D.P. (2020) Effects of chronic exposure to selenomethionine on social learning outcomes in zebrafish (Danio rerio): serotonergic dysregulation and oxidative stress in the brain. Chemosphere. 247:125898.
Abstract
For many species, social learning is crucial for fitness-related activities, but human-induced environmental changes can impair such learning processes. For instance, mining can release the element, selenium (Se), that is vital for physiological functions but also has toxicological properties at elevated concentrations. In this study, we investigated the effects of chronic exposure to Se on social learning outcomes and potential underlying molecular mechanisms in adult zebrafish. After exposure to different levels of dietary selenomethionine (control, 3.6, 12.8, 34.1 μg Se/g dry weight) for 90 days, we examined the ability of observer fish to follow demonstrators (experienced individuals) in escaping an oncoming trawl. Social learning outcomes were then assessed in the absence of demonstrators. Our results indicated that fish in the highest exposure group (34.1 μg/g) displayed significantly slower escape responses compared to fish in the control and lower exposure groups (3.6 and 12.8 μg Se/g). This impaired behavior was associated with higher oxidative stress and dysregulation in genes that are key in the serotonergic pathway, indicating that oxidative stress and alteration in the serotonergic system lead to impairment of social learning.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping