|ZFIN ID: ZDB-PUB-200122-2|
Setting up for gastrulation in zebrafish
|Source:||Current topics in developmental biology 136: 33-83 (Chapter)|
|Registered Authors:||Marlow, Florence|
|Keywords:||Anterior-posterior axis, BMP, Cell fate, Dorsal-ventral axis, Ectoderm, Endoderm, FGF, Germ layers, Gradient, Maternal, Mesoderm, Morphogenesis, Nodal, Organizer, Patterning, Signaling, TGF-β, Wnt, Zygotic|
|PubMed:||31959294 Full text @ Curr. Top. Dev. Biol.|
Marlow, F.L. (2020) Setting up for gastrulation in zebrafish. Current topics in developmental biology. 136:33-83.
ABSTRACTSoon after fertilization the zebrafish embryo generates the pool of cells that will give rise to the germline and the three somatic germ layers of the embryo (ectoderm, mesoderm and endoderm). As the basic body plan of the vertebrate embryo emerges, evolutionarily conserved developmental signaling pathways, including Bmp, Nodal, Wnt, and Fgf, direct the nearly totipotent cells of the early embryo to adopt gene expression profiles and patterns of cell behavior specific to their eventual fates. Several decades of molecular genetics research in zebrafish has yielded significant insight into the maternal and zygotic contributions and mechanisms that pattern this vertebrate embryo. This new understanding is the product of advances in genetic manipulations and imaging technologies that have allowed the field to probe the cellular, molecular and biophysical aspects underlying early patterning. The current state of the field indicates that patterning is governed by the integration of key signaling pathways and physical interactions between cells, rather than a patterning system in which distinct pathways are deployed to specify a particular cell fate. This chapter focuses on recent advances in our understanding of the genetic and molecular control of the events that impart cell identity and initiate the patterning of tissues that are prerequisites for or concurrent with movements of gastrulation.
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