PUBLICATION

Embryotoxicity assessment and efficient removal of naphthalene from water by irradiated graphene aerogels

Authors
Liu, Y., Bai, J., Yao, H., Li, G., Zhang, T., Li, S., Zhang, L., Si, J., Zhou, R., Zhang, H.
ID
ZDB-PUB-191212-5
Date
2019
Source
Ecotoxicology and environmental safety   189: 110051 (Journal)
Registered Authors
Keywords
Embryonic toxicity, Irradiated graphene aerogel, Naphthalene, Zebrafish
MeSH Terms
  • Animals
  • Water Pollutants, Chemical/analysis*
  • Water Pollutants, Chemical/toxicity
  • Zebrafish*
  • Toxicity Tests, Acute
  • Embryo, Nonmammalian/drug effects*
  • Embryonic Development/drug effects*
  • Larva/drug effects
  • Naphthalenes/analysis*
  • Naphthalenes/toxicity
  • Hydrogels
  • Surface Properties
  • Graphite/chemistry*
  • Graphite/radiation effects
  • Graphite/toxicity
PubMed
31812022 Full text @ Ecotoxicol. Environ. Saf.
Abstract
Naphthalene has remained a challenge how to eradicate it from the water because of its carcinogenic risk to humans. In the present study, naphthalene prominently increased the rates of embryonic mortality and malformation, and decreased the hatchability of zebrafish which have a high developmental similarity to humans. Moreover, multiple-organ toxicity were notably found in naphthalene-treated zebrafish. Here, irradiated graphene aerogel (IGA) was successfully prepared from high-energy electron beam to generate more wrinkles, folds, defects and a strong absorption capability for naphthalene, compared with the non-irradiated graphene aerogel. IGA was outstandingly found to remove naphthalene from the embryo culture medium, and subsequently inhibit the embryotoxicity and maintain tissue integrity by restoring cardiac function, attenuating apoptosis signals, recovering eye morphology and structure, reducing expression of heat shock protein 70 in the tissues and promoting behavioral capacity. Meanwhile, no obvious negative impact of IGA was found in the developing zebrafish from embryo to larvae. Consequently, reduction in the toxicity of naphthalene during zebrafish embryogenesis was mediated by IGA as an advanced strategy.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping