|ZFIN ID: ZDB-PUB-191111-18|
Origin and development of circumventricular organs in living vertebrate
Korzh, V., Kondrychyn, I.
|Source:||Seminars in cell & developmental biology 102: 13-20 (Review)|
|Registered Authors:||Kondrychyn, Igor, Korzh, Vladimir|
|Keywords:||Enhancer-Trap transgenics, Fenestrated capillaries, Floor plate, Low Wnt/ β-catenin signaling, Roof plate, Zebrafish|
|PubMed:||31706729 Full text @ Sem. Cell Dev. Biol.|
Korzh, V., Kondrychyn, I. (2019) Origin and development of circumventricular organs in living vertebrate. Seminars in cell & developmental biology. 102:13-20.
ABSTRACTThe circumventricular organs (CVOs) function by mediating chemical communication between blood and brain across the blood-brain barrier. Their origin and developmental mechanisms involved are not understood in enough detail due to a lack of molecular markers common for CVOs. These rather small and inconspicuous organs are found in close vicinity to the third and fourth brain ventricles suggestive of ancient evolutionary origin. Recently, an integrated approach based on analysis of CVOs development in the enhancer-trap transgenic zebrafish led to an idea that almost all of CVOs could be highlighted by GFP expression in this transgenic line. This in turn suggested that an enhancer along with a set of genes it regulates may illustrate the first common element of developmental regulation of CVOs. It seems to be related to a mechanism of suppression of the canonical Wnt/ β-catenin signaling that functions in development of fenestrated capillaries typical for CVOs. Based on that observation the common molecular elements of the putative developmental mechanism of CVOs will be discussed in this review.
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