ZFIN ID: ZDB-PUB-191024-7
Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish
Sande-Melón, M., Marques, I.J., Galardi-Castilla, M., Langa, X., Pérez-López, M., Botos, M.A., Sánchez-Iranzo, H., Guzmán-Martínez, G., Ferreira Francisco, D.M., Pavlinic, D., Benes, V., Bruggmann, R., Mercader, N.
Date: 2019
Source: Cell Reports   29: 1041-1054.e5 (Journal)
Registered Authors: Marques, Ines, Mercader Huber, Nadia
Keywords: cardiomyocyte proliferation, heart regeneration, sox10, zebrafish
Microarrays: GEO:GSE133571
MeSH Terms: none
PubMed: 31644901 Full text @ Cell Rep.
ABSTRACT
During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identify a subset of preexistent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded after cryoinjury. Genetic ablation of sox10+ cardiomyocytes impairs cardiac regeneration, revealing that these cells play a role in heart regeneration.
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