PUBLICATION
Parental exposure to triphenyltin inhibits growth and disrupts thyroid function in zebrafish larvae
- Authors
- Li, P., Li, Z.H., Zhong, L.
- ID
- ZDB-PUB-191001-13
- Date
- 2019
- Source
- Chemosphere 240: 124936 (Journal)
- Registered Authors
- Keywords
- Growth inhibition, Parental exposure, Thyroid system disruption, Triphenyltin, Zebrafish
- MeSH Terms
-
- Animals
- Female
- Growth Hormone/genetics
- Growth Hormone/metabolism
- Larva/drug effects
- Larva/growth & development*
- Male
- Maternal Exposure/adverse effects
- Organotin Compounds/toxicity*
- Paternal Exposure/adverse effects
- Pesticides/toxicity*
- Somatomedins/genetics
- Somatomedins/metabolism
- Thyroid Gland/drug effects
- Thyroid Gland/pathology*
- Thyroxine/blood
- Triiodothyronine/blood
- Water Pollutants, Chemical/toxicity*
- Zebrafish/embryology
- PubMed
- 31568941 Full text @ Chemosphere
Citation
Li, P., Li, Z.H., Zhong, L. (2019) Parental exposure to triphenyltin inhibits growth and disrupts thyroid function in zebrafish larvae. Chemosphere. 240:124936.
Abstract
Triphenyltin (TPT) is widely used and commonly found in a water environment, so its effects on aquatic systems are of great concern. This study aimed to reveal the effects of chronic parental exposure of TPT on thyroid disruption and growth inhibition in zebrafish. Adult zebrafish (F0 generation) were exposed to environmentally relevant concentrations (1, 10, and 100 ng/L) of TPT for 60 days, and the larvae (F1 generation) were tested without TPT treatment. Results demonstrated that parental exposure to TPT disrupts thyroid function in zebrafish offspring: serum thyroxine (T4) significantly decreased, while serum 3,5,3'-triiodothyronine (T3) increased, and several genes involved in the hypothalamic-pituitary-thyroid (HPT) axis were down-regulated. In addition, we observed developmental abnormalities in the larvae, demonstrated by a significantly altered hatching rate, malformation rate, body length, heart rate, and survival rate, as well as down-regulation of genes involved in the growth hormone/insulin-like growth factor (GH/IGF) axis. Therefore, parental exposure to TPT induces toxicity in fish offspring through perturbation of the HPT and GH/IGF axes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping