PUBLICATION
Hierarchical control of locomotion by distinct types of spinal V2a interneurons in zebrafish
- Authors
- Menelaou, E., McLean, D.L.
- ID
- ZDB-PUB-190915-3
- Date
- 2019
- Source
- Nature communications 10: 4197 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Interneurons/cytology
- Interneurons/metabolism*
- Locomotion/physiology*
- Motor Neurons/cytology
- Motor Neurons/metabolism
- Spinal Cord/cytology
- Spinal Cord/metabolism
- Zebrafish
- PubMed
- 31519892 Full text @ Nat. Commun.
Citation
Menelaou, E., McLean, D.L. (2019) Hierarchical control of locomotion by distinct types of spinal V2a interneurons in zebrafish. Nature communications. 10:4197.
Abstract
In all vertebrates, excitatory spinal interneurons execute dynamic adjustments in the timing and amplitude of locomotor movements. Currently, it is unclear whether interneurons responsible for timing control are distinct from those involved in amplitude control. Here, we show that in larval zebrafish, molecularly, morphologically and electrophysiologically distinct types of V2a neurons exhibit complementary patterns of connectivity. Stronger higher-order connections from type I neurons to other excitatory V2a and inhibitory V0d interneurons provide timing control, while stronger last-order connections from type II neurons to motor neurons provide amplitude control. Thus, timing and amplitude are coordinated by distinct interneurons distinguished not by their occupation of hierarchically-arranged anatomical layers, but rather by differences in the reliability and probability of higher-order and last-order connections that ultimately form a single anatomical layer. These findings contribute to our understanding of the origins of timing and amplitude control in the spinal cord.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping