PUBLICATION

Modeling hematopoietic disorders in zebrafish

Authors
Konantz, M., Schürch, C., Hanns, P., Müller, J.S., Sauteur, L., Lengerke, C.
ID
ZDB-PUB-190915-2
Date
2019
Source
Disease models & mechanisms   12(9): (Other)
Registered Authors
Hanns, Pauline, Konantz, Martina, Lengerke, Claudia, Müller, Joëlle, Sauteur, Loïc, Schürch, Christoph
Keywords
Blood disorders, Bone marrow failure syndrome, Disease models, Hematopoiesis, Immunodeficiency, Leukemia
MeSH Terms
  • Animals
  • Disease Models, Animal*
  • Drug Evaluation, Preclinical
  • Hematologic Diseases/pathology*
  • Hematopoiesis*
  • Zebrafish/physiology*
PubMed
31519693 Full text @ Dis. Model. Mech.
Abstract
Zebrafish offer a powerful vertebrate model for studies of development and disease. The major advantages of this model include the possibilities of conducting reverse and forward genetic screens and of observing cellular processes by in vivo imaging of single cells. Moreover, pathways regulating blood development are highly conserved between zebrafish and mammals, and several discoveries made in fish were later translated to murine and human models. This review and accompanying poster provide an overview of zebrafish hematopoiesis and discuss the existing zebrafish models of blood disorders, such as myeloid and lymphoid malignancies, bone marrow failure syndromes and immunodeficiencies, with a focus on how these models were generated and how they can be applied for translational research.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes