PUBLICATION
Modeling hematopoietic disorders in zebrafish
- Authors
- Konantz, M., Schürch, C., Hanns, P., Müller, J.S., Sauteur, L., Lengerke, C.
- ID
- ZDB-PUB-190915-2
- Date
- 2019
- Source
- Disease models & mechanisms 12(9): (Other)
- Registered Authors
- Hanns, Pauline, Konantz, Martina, Lengerke, Claudia, Müller, Joëlle, Sauteur, Loïc, Schürch, Christoph
- Keywords
- Blood disorders, Bone marrow failure syndrome, Disease models, Hematopoiesis, Immunodeficiency, Leukemia
- MeSH Terms
-
- Disease Models, Animal*
- Hematologic Diseases/pathology*
- Animals
- Hematopoiesis*
- Drug Evaluation, Preclinical
- Zebrafish/physiology*
- PubMed
- 31519693 Full text @ Dis. Model. Mech.
Citation
Konantz, M., Schürch, C., Hanns, P., Müller, J.S., Sauteur, L., Lengerke, C. (2019) Modeling hematopoietic disorders in zebrafish. Disease models & mechanisms. 12(9).
Abstract
Zebrafish offer a powerful vertebrate model for studies of development and disease. The major advantages of this model include the possibilities of conducting reverse and forward genetic screens and of observing cellular processes by in vivo imaging of single cells. Moreover, pathways regulating blood development are highly conserved between zebrafish and mammals, and several discoveries made in fish were later translated to murine and human models. This review and accompanying poster provide an overview of zebrafish hematopoiesis and discuss the existing zebrafish models of blood disorders, such as myeloid and lymphoid malignancies, bone marrow failure syndromes and immunodeficiencies, with a focus on how these models were generated and how they can be applied for translational research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping