PUBLICATION
Zebrafish as a Model of Neurodevelopmental Disorders
- Authors
- de Abreu, M.S., Genario, R., Giacomini, A.C.V.V., Demin, K.A., Lakstygal, A.M., Amstislavskaya, T.G., Fontana, B.D., Parker, M.O., Kalueff, A.V.
- ID
- ZDB-PUB-190902-25
- Date
- 2019
- Source
- Neuroscience 445: 3-11 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- animal models, attention-deficit/hyperactivity disorder, autism, genetic models, neurodevelopment
- MeSH Terms
-
- Animals
- Brain
- Disease Models, Animal
- Humans
- Models, Animal
- Neurodevelopmental Disorders*
- Quality of Life
- Zebrafish*
- PubMed
- 31472215 Full text @ Neuroscience
Citation
de Abreu, M.S., Genario, R., Giacomini, A.C.V.V., Demin, K.A., Lakstygal, A.M., Amstislavskaya, T.G., Fontana, B.D., Parker, M.O., Kalueff, A.V. (2019) Zebrafish as a Model of Neurodevelopmental Disorders. Neuroscience. 445:3-11.
Abstract
Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are a valuable tool for studying NDD pathobiology and therapies. Mounting evidence suggests the zebrafish (Danio rerio) as a useful model organism to study NDDs with high physiological homology to humans and sensitivity to pharmacological and genetic manipulations. Here, we summarize experimental models of NDDs in zebrafish and highlight the growing translational significance of zebrafish NDD-related phenotypes. We also emphasize the need in further development of zebrafish models of NDDs to improve our understanding of their pathogenesis and therapeutic treatments.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping