PUBLICATION
White Environment Can Be Used as an Aversive Stimulus in Zebrafish Inhibitory Avoidance Learning
- Authors
- Santos, B.R.D., Santos, R.C.D., Dias, C.A.G.M., Maximino, C., Gouveia, A.
- ID
- ZDB-PUB-190823-10
- Date
- 2019
- Source
- Zebrafish 16(5): 443-450 (Journal)
- Registered Authors
- Maximino, Caio
- Keywords
- anxiety, inhibitory avoidance, learning, psychiatric drugs, zebrafish
- MeSH Terms
-
- Animals
- Antidepressive Agents, Tricyclic/administration & dosage
- Antidepressive Agents, Tricyclic/pharmacology*
- Avoidance Learning/drug effects*
- Female
- Fluoxetine/administration & dosage
- Fluoxetine/pharmacology*
- Imipramine/administration & dosage
- Imipramine/pharmacology*
- Male
- Maze Learning
- Selective Serotonin Reuptake Inhibitors/administration & dosage
- Selective Serotonin Reuptake Inhibitors/pharmacology*
- Zebrafish/physiology
- PubMed
- 31436486 Full text @ Zebrafish
Citation
Santos, B.R.D., Santos, R.C.D., Dias, C.A.G.M., Maximino, C., Gouveia, A. (2019) White Environment Can Be Used as an Aversive Stimulus in Zebrafish Inhibitory Avoidance Learning. Zebrafish. 16(5):443-450.
Abstract
The two-factor theory predicts that the acquisition of avoidance responses is dependent on fear reduction; as such, drugs that reduce or increase fear or anxiety states should alter inhibitory avoidance (IA) acquisition. The present experiment used white spaces as aversive unconditioned stimuli in IA in zebrafish. Adult zebrafishes were tested in three experiments: validation of white compartment as aversive in IA; open field test; and effect of antidepressant (fluoxetine, imipramine) and anxiolytic (diazepam, clonazepam). The data show the effectiveness of the white compartment as an aversive stimulus in IA. Antidepressant fluoxetine did not alter and imipramine impairs avoidance acquisition in higher doses. Imipramine also produced a sedative effect in lower doses. Anxiolytic and stimulant drugs facilitated learning at doses which did not impair locomotion, suggesting that pharmacological manipulation of other factors in addition to fear/anxiety can impact aversive learning in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping